Advancements in the preparation of high-performance liquid chromatographic organic polymer monoliths for the separation of small-molecule drugs  

作　　者：Xiali Ding Jing Yang Yuming Dong 

机构地区：[1]Institute of Pharmaceutical Analysis,School of Pharmacy,Lanzhou University,Lanzhou,Gansu 730000,PR China [2]Lanzhou Universty-Techcomp(China)Ltd.Joint Laboratory of Pharmaceutical Analysis,Lanzhou,Gansu 730000,PR China

出　　处：《Journal of Pharmaceutical Analysis》2018年第2期75-85,共11页药物分析学报（英文版）

摘　　要：The various advantages of organic polymer monoliths, including relatively simple preparation processes,abundant monomer availability, and a wide application range of pH, have attracted the attention of chromatographers. Organic polymer monoliths prepared by traditional methods only have macropores and mesopores, and micropores of less than 50 nm are not commonly available. These typical monoliths are suitable for the separation of biological macromolecules such as proteins and nucleic acids, but their ability to separate small molecular compounds is poor. In recent years, researchers have successfully modified polymer monoliths to achieve uniform compact pore structures. In particular, microporous materials with pores of 50 nm or less that can provide a large enough surface area are the key to the separation of small molecules. In this review, preparation methods of polymer monoliths for high-performance liquid chromatography, including ultra-high cross-linking technology, post-surface modification, and the addition of nanomaterials, are discussed. Modified monolithic columns have been used successfully to separate small molecules with obvious improvements in column efficiency.The various advantages of organic polymer monoliths, including relatively simple preparation processes,abundant monomer availability, and a wide application range of pH, have attracted the attention of chromatographers. Organic polymer monoliths prepared by traditional methods only have macropores and mesopores, and micropores of less than 50 nm are not commonly available. These typical monoliths are suitable for the separation of biological macromolecules such as proteins and nucleic acids, but their ability to separate small molecular compounds is poor. In recent years, researchers have successfully modified polymer monoliths to achieve uniform compact pore structures. In particular, microporous materials with pores of 50 nm or less that can provide a large enough surface area are the key to the separation of small molecules. In this review, preparation methods of polymer monoliths for high-performance liquid chromatography, including ultra-high cross-linking technology, post-surface modification, and the addition of nanomaterials, are discussed. Modified monolithic columns have been used successfully to separate small molecules with obvious improvements in column efficiency.

关 键 词：HIGH-PERFORMANCE LIQUID chromatography Polymer MONOLITH Preparation methods Small molecules 

分 类 号：R[医药卫生]