学龄期腭裂儿童的事件相关电位研究  

Study of event-related potentials in school-age children with cleft palate

作　　者：束煌[1] 杨峰[2] 王骥[1] 肖宇寒[3] 丁桂聪[1] SHU Huang;YANG Feng;WANG Ji;XIAO Yuhan;DING Guicong(Department of Stomatology,Shenzhen Children's Hospital,Shenzhen 518026,China;Department of Speech Therapy,Shenzhen Children's Hospital,Shenzhen 518026,China;Evoked Poten.tials Laboratory,Shenzhen Children's Hospital,Shenzhen 518026,China)

机构地区：[1]深圳市儿童医院口腔科,广东深圳518026 [2]深圳市儿童医院言语治疗科,广东深圳518026 [3]深圳市儿童医院诱发电位室,广东深圳518026

出　　处：《口腔疾病防治》2018年第4期236-239,共4页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：深圳市科创委基础研究项目(JCYJ20150403100317070)

摘　　要：目的通过观察学龄期腭裂儿童的事件相关电位中P300、N400成分的特征,探讨腭裂儿童是否存在中枢性听觉处理功能和语言功能障碍。方法选取6~12岁学龄期腭裂儿童28例,分别检测其事件相关电位中P300、N400成分,并与年龄相匹配的正常儿童30例作比较,进行统计学分析。结果腭裂儿童的P300潜伏期为(348.64±14.66)ms,波幅为(12.07±2.46)μV;正常儿童P300潜伏期为(331.73±14.94)ms,波幅为(13.47±2.24)μV;两组比较,腭裂儿童P300潜伏期延长,波幅降低,差异有统计学意义(P<0.05)。腭裂儿童的N400潜伏期为(431.07±17.90)ms,波幅为(13.75±2.12)μV;正常儿童N400潜伏期为(408.23±18.04)ms,波幅为(15.17±2.34)μV;两组比较,腭裂儿童N400潜伏期延长,波幅降低,差异有统计学意义(P<0.05)。结论学龄期腭裂儿童可能存在中枢性听觉处理功能和语言功能障碍。Objective To investigate possible functional disorders of central auditory processing and language in school-age children with cleft palate through an assessment of the characteristics of the P300 and N400 event-related potentials(ERPs).Methods This study included 28 school-age children with cleft palate,aged 6 to 12 years,and 30 children without cleft palate as a control group.The P300 and N400 ERPs were selected as indexes of the central auditory processing and language functions of children in both groups.The data were statistically compared between the two groups.Results Compared with the controls,the children with cleft palate showed a significantly prolonged P300 latency(331.73±14.94 ms vs.348.64±14.66 ms,P<0.05)and a significantly decreased P300 amplitude(13.47±2.24μV vs.12.07±2.46μV,P<0.05).Similarly,the N400 latency of children with cleft palate was significantly prolonged compared to that of controls(431.07±17.90 ms vs.408.23±18.04 ms,P<0.05),and the N400 amplitude was significantly decreased compared to that of controls(13.75±2.12μV vs.15.17±2.34μV,P<0.05).Conclusion School-age children with cleft palate may have central auditory processing disorders and language dysfunctions.

关 键 词：腭裂 学龄期儿童 事件相关电位 中枢性听觉处理障碍 语言障碍 

分 类 号：R782.2[医药卫生—口腔医学]