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作 者:韩静 刘庆 HAN Jing;LIU Qing(Jiren Hospital of Huyi District,Xi'an 710300;the Hospital of Gaoling District,Xi'an 710200,China)
机构地区:[1]鄠邑区济仁医院,陕西西安710300 [2]高陵区医院,陕西西安710200
出 处:《临床医学研究与实践》2018年第11期70-71,共2页Clinical Research and Practice
摘 要:目的探讨术前新辅助化疗对卵巢癌手术患者的临床疗效及血清肿瘤标志物的影响。方法选择我院2016年3月至2017年6月收治的卵巢癌手术患者70例,随机分为对照组和试验组,各35例。对照组于卵巢癌手术后接受化疗,试验组则在卵巢癌手术前接受新辅助化疗。比较两组临床效果。结果试验组患者的临床有效率明显高于对照组(P<0.05)。治疗后,两组血清CA125、CA19-9、CEA和NSE水平明显降低,试验组明显低于对照组(P<0.05)。试验组患者的生活质量四个维度评分和总评分均明显高于对照组(P<0.05)。结论对于卵巢癌手术患者来说,术前新辅助化疗能够显著提高患者的临床疗效和生活质量,并且能够降低患者的血清肿瘤标志物水平,改善患者的预后。Objective To investigate the effect of preoperative neoadjuvant chemotherapy on efficacy and serum tumor markers in patients with ovarian cancer.Methods Seventy patients with ovarian cancer treated in our hospital from March 2016 to June 2017 were randomly divided into control group and experimental group,with 35 cases in each group.The control group received chemotherapy after ovarian cancer surgery,and the experimental group received neoadjuvant chemotherapy prior to ovarian cancer surgery.The clinical effects were compared between the two groups.Results The clinical effective rate of the experimental group was higher than that of the control group(P<0.05).After treatment,serum CA125,CA19-9,CEA and NSE levels decreased in the two groups,and those in the experimental group were lower than the control group(P<0.05).The four-dimension scores and total score of the quality of life in the experimental group were higher than those in the control group(P<0.05).Conclusion Preoperative neoadjuvant chemotherapy can improve the clinical efficacy and quality of life of patients with ovarian cancer,reduce the levels of serum tumor markers,and improve the prognosis of patients.
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