脑苷肌肽联合常规方案治疗血管性痴呆的疗效和安全性系统评价  

Efficacy and Safety of Cattle Encephalon Glycoside and Ignotin Injection for Vascular Dementia:a Systematic Review

作　　者：王云锋[1,2] 谢韵漪 赵志刚 李笛天[4] 杨兴华 Wang Yunfeng;Xie Yunyi;Zhao Zhigang;Li Ditian;Yang Xinghua(School of Public Health,Capital Medical University,Beijing 100069,China;Municipal Key Laboratory of Clinical Epidemiology,Beijing 100069,China)

机构地区：[1]首都医科大学公共卫生学院,北京100069 [2]临床流行病学北京市重点实验室 [3]首都医科大学附属北京天坛医院 [4]北京大学医学部基础医学院

出　　处：《中西医结合心脑血管病杂志》2018年第6期694-699,共6页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的系统评价脑苷肌肽治疗血管性痴呆的疗效和安全性。方法计算机检索PubMed、Embase、Cochrane Library、CNKI、VIP、CBM和万方数据库,搜集有关脑苷肌肽治疗血管性痴呆的随机对照试验(RCT),按照纳入与排除标准进行文献筛选、资料提取和评价纳入研究的偏倚风险后,采用RevMan5.3统计软件进行Meta分析。结果共纳入7项RCT,481例病人。Meta分析结果显示:5项RCT表明,与胞二磷胆碱相比,脑苷肌肽可提高简易智能精神状态量表(MMSE)评分[MD=3.46,95%CI(2.81,4.10),Z=10.48,P<0.001],能显著提高总有效率[RR=2.07,95%CI(1.41,3.04),Z=3.71,P<0.001],能显著降低ADL评分[MD=-4.77,95%CI(-6.48,-3.06),Z=5.46,P<0.001];7项研究总MMSE得分,与胞二磷胆碱、尼莫地平、银杏叶注射液等药物相比,脑苷肌肽可提高MMSE评分[MD=3.19,95%CI(2.62,3.76),Z=10.95,P<0.001]。结论基于现有临床证据,脑苷肌肽用于治疗血管性痴呆具有有效性和安全性。Objective To systematically review the efficacy and safety of cattle encephalon glycoside and ignotin injection for vascular dementia.Methods China National Knowledge Infrastructure(CNKI),VIP Database,WanFang Data,Chinese Biomedical Literature Database(CBM),PubMed,Embase and Cochrane Library were searched to collect randomized controlled trials(RCTs)about cattle enceph alon glycoside and ignotin injection for vascular dementia.After quality evaluation and data extraction meta-analysis was performed by Rev Man 5.3 software.Results A total of 7 RCTs involving 481 patients were included.The results of meta-analysis showed that,the MMSE scores[MD=3.46,95%CI(2.81,4.10),Z=10.48,P<0.001]in cattle encephalon glycoside and ignotin injection group were higher than in control group treated with cytidine diphosphate choline.And compared with cytidine diphosphate choline,cattle encephalon glycoside and ignotin injection increase the total effective rate by 2.07 times[RR=2.07,95%CI(1.41,3.04),Z=3.71,P=0.001]and the ADL scores decrease[MD=-4.77,95%CI(-6.48,-3.06),Z=5.46,P<0.001]with sign ificant differences.And the efficacy of the cattle encephalon glycoside and ignotin in jectttion group was superior to that of the control group treated with cytidine diphos phatecholine,nimodipine and folium ginkgo injection in MMSE[MD=3.19,95%CI(2.62,3.76),Z=10.95,P<0.001].Conclusion Current evidence shows that cattle encephalon glycoside and ignotin injection can increase MMSE scores,the total effective rate,and decrease the ADL scores.

关 键 词：血管性痴呆 脑苷肌肽 系统评价 随机对照试验 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R255.2[医药卫生—临床医学]