结直肠进展期腺瘤危险因素分析  

Analysis of risk factors for advanced colorectal adenomas

作　　者：翟爱军[1] 陈洪[1] 张续乾 田正凤[1] 王亚东[2] 杨文珍[2] 刘茉[2] 王贵齐[3] 贺舜[3] Zhai Aijun;Chen Hong;Zhang Xuqian(Department of Gastroenterology and Hematology,No.731 Hospital of CASIC,100074 Beijing,China)

机构地区：[1]中国航天科工集团七三一医院消化及血液内科,北京100074 [2]首都医科大学卫生管理与教育学院 [3]中国医学科学院肿瘤医院内镜科

出　　处：《中华保健医学杂志》2018年第2期102-104,共3页Chinese Journal of Health Care and Medicine

基　　金：北京市科学技术委员会资助项目(D121100004712001)

摘　　要：目的探讨结直肠进展期腺瘤发病的相关危险因素。方法选取2013年3月～2016年2月在中国航天科工集团七三一医院消化内科门诊就诊,行免疫法粪便隐血试验(IFOBT)及结肠镜检查的人群804例。对符合纳入与排除标准的以发现有进展期腺瘤的患者为病例组,以结肠镜检查未见异常者为对照组,进行问卷调查,应用SPSS17.0软件对数据进行统计学分析。结果两组受检者单因素分析结果显示,性别、便秘影响结直肠进展期腺瘤的发生(P<0.05);多因素Logistic回归分析结果显示,性别(OR=1.651,P=0.002)、年龄(OR=1.336,P<0.001)、一级亲属结直肠癌史(OR=1.534,P=0.048)、粪便隐血阳性(OR=1.442,P=0.043)是结直肠进展期腺瘤的独立危险因素。结论男性、年龄越大、一级亲属有结直肠癌史、粪便隐血阳性的人群患结直肠进展期腺瘤的风险较高。Objective To explore the risk factors for advanced colorectal adenomas.Methods 804 patients who underwent immunochemical fecal occult blood tests(iFOBT)and complete colonoscopy at the Department of Gastroenterology and Hematology No.731 Hospital of China Aerospace Science&Industry Corporation(CASIC)between Mar 2013 and Feb 2016 were enrolled into this study.These patients were divided into either the case group or the normal control group based on the different colonoscopy results.Each subject answered the same questionnaire.The data were statistically analyzed by SPSS17.0 software.Results A univariate analysis showed that gender and constipation affected the incidence of advanced colorectal adenomas(P<0.05).A multivariate logistic regression analysis showed that gender(OR=1.651,P=0.002),age(OR=1.336,P<0.001),family history of colorectal cancer in a first-degree relative(OR=1.534,P=0.048)and positivity for fecal occult blood(OR=1.442,P=0.043)were independent risk factors for advanced colorectal adenomas.Conclusion Male gender,old age,a family history of colorectal cancer in a first-degree relative and positivity of fecal occult blood are risk factors for advanced colorectal adenomas.

关 键 词：结直肠进展期腺瘤 危险因素 问卷调查 结直肠癌 

分 类 号：R735.35[医药卫生—肿瘤]