表皮生长因子受体-细胞外信号调节激酶信号通路在缺血性脑血管病中的相关研究进展  

The related research progress of epidermal growth factor receptor-ex-tracellular signal regulated kinase signaling pathway in the ischemic cere-brovascular disease

作　　者：张芹 奥婷 肖淑英[1] 许娜 张瑞华[1] ZHANG Qin;AO Ting;XIAO Shuying;XU Na;ZHANG Ruihua(Department of Geriatric Medicine,Luhe Hospital,Capital Medical University,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京潞河医院老年医学科,北京101149

出　　处：《中国医药导报》2018年第9期36-40,共5页China Medical Herald

基　　金：北京市通州区科技计划项目(KJ2017CX036-15)

摘　　要：缺血性脑血管病是常见的慢性致残性疾病,严重影响患者生活质量。研究表明,表皮生长因子受体-细胞外信号调节激酶(EGFR-ERK)通路在缺血性脑血管病的病理生理过程中发挥了重要的作用,但具体机制不详。因此,本文对该通路在缺血性脑血管病中的相关研究进展作一综述,为缺血性脑血管病的进一步基础研究及临床治疗提供参考。Ischemic cerebrovascular disease(ICD)is a common chronic disabling disease.This disease seriously affects the quality of lives of patients.The research shows that the epidermal growth factor receptor-extracellular signal regulated kinase(EGFR-ERK)pathway plays an important role on the pathophysiology process in ICD.However,the mechanism is still unclear.This article reviews the progress of the EGFR-ERK pathway in ICD,which provides references for further basic research and clinical treatment of ICD.

关 键 词：表皮生长因子受体 细胞外信号调节激酶 EGFR-ERK信号通路 缺血性脑血管病 

分 类 号：R743[医药卫生—神经病学与精神病学]