榄香烯注射液辅助治疗晚期胃癌的临床观察  

Clinical Observation of Elemene Injection in the Treatment of Advanced Gastric Cancer

作　　者：王丽萍[1] 吴琼[2] 周延[3] 庞国勋[3] WANG Li-ping;WU Qiong;ZHOU Yan;PANG Guo-xun(Emergency Department,Tangshan General Hospital,Tangshan,Hebei 063000,China;Department of Oncology,Tangshan General Hospital,Tangshan,Hebei 063000,China;Pharmacy Department,Hebei General Hospital,Shijiazhuang 050051,China)

机构地区：[1]唐山市人民医院急诊科,唐山063000 [2]唐山市人民医院肿瘤科,唐山063000 [3]河北省人民医院药学部,石家庄050051

出　　处：《临床误诊误治》2018年第4期81-84,共4页Clinical Misdiagnosis & Mistherapy

基　　金：河北省2017年度医学科学研究重点课题计划(20170352)

摘　　要：目的观察榄香烯注射液联合XELOX方案治疗晚期胃癌的效果和安全性。方法选取唐山市人民医院和河北省人民医院2013年1月—2015年1月收治的60例晚期胃癌,根据治疗方法的不同分为观察组和对照组各30例。两组均给予XELOX方案(奥沙利铂+卡培他滨)化疗,观察组在化疗基础上加用榄香烯注射液600 mg每日1次静脉滴注,连用1周。两组均以3周为1个治疗周期,共治疗6个周期。6个治疗周期结束后,对两组疗效及安全性进行评估。结果治疗6个周期后,观察组行为状态量表评分(KPS)高于治疗前(t=15.133,P<0.001),且治疗后观察组KPS评分亦高于对照组(t=10.861,P<0.001);观察组总有效率和疾病控制率均优于对照组,差异均有统计学意义(χ~2=4.338,P=0.037;χ~2=17.543,P<0.001)。观察组治疗期间化疗不良反应发生率较对照组显著降低(P<0.05或P<0.01);观察组榄香烯注射液应用主要不良反应是静脉炎、过敏等,均经对症处理痊愈。观察组中位生存时间为13.8个月长于对照组的11.5个月,但差异无统计学意义(t=3.561,P=0.059)。结论榄香烯注射液联合XELOX方案治疗晚期胃癌,可提高患者疗效,缓解化疗不良反应,改善生活质量。Objective To observe the therapeutic effect and safety of elemene injection combined with XELOX regimen in the treatment of advanced gastric cancer.Methods A total of 60 patients with advanced gastric cancer admitted to Tangshan General Hospital and Hebei General Hospital from January 2013 to January 2015 were randomly divided into control group(n=30)and treatment group(n=30)according to random number table method.The patients in the control group received chemotherapy with XELOX(Oxaliplatin+Capecitabine)alone.Those in the treatment group were treated with intravenous infusion of elemene injection(600 mg/day once for a consecutive week)on the basis of chemotherapy.After six cycles of chemotherapy,the therapeutic efficacy in the two groups was evaluated.Results The KPS score of the treatment group was significantly higher than that of the control group before treatment(t=15.133,P<0.001)and after treatment(t=10.861,P<0.001).The objective response rate and disease control rate were higher in the treatment group than in the control group,and the difference was statistically significant(χ2=4.338,P=0.037;χ2=17.543,P<0.001).The incidence of adverse reactions was significantly lower in the treatment group than in the control group(P<0.05 or P<0.01).The most common side effects of elemene injection in the treatment group were phlebitis and allergies.In addition,the median OS was longer in the treatment group than in the control group(13.8 months vs 11.5 months,t=3.561,P=0.059).Conclusion Elemene injection combined with XELOX regimen for advanced gastric cancer can significantly improve clinical efficacy,relieve side effects by chemotherapy,and improve quality of life.

关 键 词：胃肿瘤 榄香烯注射液 抗肿瘤联合化疗方案 

分 类 号：R735.2[医药卫生—肿瘤]