甲状腺癌术后碘^(131)治疗对唾液腺功能及生命质量的影响效果分析  

Analysis of Iodine^(131) Treatment′s Influence on Salivary Glands Function and Life Quality after Thyroid Cancer Surgery

作　　者：张凤萍[1] 张美春[1] Zhang Fengping;Zhang Meichun(Department of Nuclear Medicine,General Hopital of Lanzhou Military Region,Lanzhou 730050,China)

机构地区：[1]兰州军区兰州总医院核医学科,甘肃兰州730050

出　　处：《甘肃科学学报》2018年第2期54-58,共5页Journal of Gansu Sciences

摘　　要：分析甲状腺癌术后碘^(131)治疗对唾液腺功能及生命质量的影响效果。选取2016年1月—12月于我院接受手术及术后碘^(131)治疗的60例甲状腺癌患者为研究对象,在征得患者知情同意下对其进行为期1年的随访,对比碘^(131)治疗对唾液腺功能及生命质量的影响效果。结果发现,治疗前60例甲状腺癌患者唾液腺摄取功能(正常、轻度下降、中度下降、重度下降)及唾液腺分泌功能(正常、轻度障碍、中度障碍、重度障碍)占比分别为78.33%、20.00%、1.67%、0和75.00%、21.67%、3.33%、0,治疗后占比分别为55.00%、33.33%、8.33%、3.33%和56.67%、31.67%、6.67%、5.00%,差异均有统计学意义(P<0.05);治疗前生命质量(生理、心理、独立性、社会功能、环境、精神)评分依次为(13.44±1.06)分、(12.77±1.03)分、(13.45±1.05)分、(12.89±1.11)分、(13.55±1.05)分、(12.87±1.03)分,治疗后依次为(17.64±1.04)分、(17.81±1.09)分、(18.10±1.04)分、(16.34±1.06)分、(16.58±1.02)分、(17.77±1.07)分,差异有统计学意义(P<0.05);不同碘^(131)治疗剂量下唾液腺摄取功能和唾液腺分泌功能相比较,低剂量者占比分别为21.67%、3.33%、1.67%、0和23.33%、1.67%、1.67%、0,中剂量者占比分别为33.33%、25.00%、3.33%、1.67%和33.33%、26.67%、1.67%、1.67%,高剂量者占比分别为33.33%、25.00%、3.33%、1.67%和33.33%、26.67%、1.67%、1.67%,差异均有统计学意义(P<0.05);不同碘^(131)治疗剂量下生命质量比较,低剂量者依次为(16.33±1.04)分、(16.39±1.01)分、(16.38±1.02)分、(15.10±1.07)分、(15.41±1.03)分、(15.78±1.03)分,中剂量者依次为(18.67±1.03)分、(18.43±1.02)分、(18.99±1.00)分、(18.04±1.06)分、(17.49±1.02)分、(18.94±1.01)分,高剂量者依次为(17.52±1.02)分、(17.60±1.05)分、(17.57±1.01)分、(16.68±1.04)分、(16.50±1.05)分、(17.55±1.05)分,差异均有统计学意义(P<0.05)。说明甲状腺癌术后碘^(131)治疗有助于提高患者生命�Analysis of iodine 131 treatment′s influence on salivary glands function and life quality after thyroid cancer surgery.Take 60 patients with thyroid cancer who accepted surgery and postoperative iodine 131 treatment in our hospital during Jan.2016-Dec.2016 as the research objects,carry out one-year follow-up visit for them after asking patients for their permission,then,compare the iodine 131 treatment′s influence on salivary gland function and life quality.The salivary gland function(normal,mild decline,moderate decline and severe decline)and salivary gland secretion(normal,mild disability,moderate disability and severe disability)of 60 patients with thyroid cancer before treatment accounts for 78.33%,20.00%,1.67%,0 and 75.00%,21.67%,3.33%,0 respectively.After treatment,the foregoing proportion reaches up to 55.00%,33.33%,8.33%,3.33%and 56.67%,31.67%,6.67%,5.00%.Hence,the difference has the statistical significance(P<0.05).The score of life quality(physiology,psychology,independence,social function,environment and spirit)before treatment is 13.44±1.06,12.77±1.03,13.45±1.05,12.89±1.11,13.55±1.05 and 12.87±1.03 respectively.After treatment,the score is 17.64±1.04,17.81±1.09,18.10±1.04,16.34±1.06,16.58±1.02 and 17.77±1.07.Hence,the difference has the statistical significance(P<0.05).When the intake function of salivary gland function is compared with its secretion function under different iodine 131 treatment doses,the low dose accounts for 21.67%,3.33%,1.67%,0 and 23.33%,1.67%,1.67%,0,the moderate dose accounts for 33.33%,25.00%,3.33%,1.67%and 33.33%,26.67%,1.67%,1.67%;the high dose accounts for 33.33%,25.00%,3.33%,1.67%and 33.33%,26.67%,1.67%,1.67%.Hence,the difference has the statistical significance(P<0.05).When the life quality is compared under different iodine 131 treatment doses,the low dose score is 16.33±1.04,16.39±1.01,16.38±1.02,15.10±1.07,15.41±1.03 and 15.78±1.03,the moderate dose score is 18.67±1.03,18.43±1.02,18.99±1.00,18.04±1.06,17.49±1.02 and 18.94±1.01,the high dose s

关 键 词：甲状腺癌 碘131 唾液腺功能 生命质量 

分 类 号：R736.1[医药卫生—肿瘤]