针刺治疗恶性肿瘤高凝状态临床研究  

Clinical Effect of Acupuncture in Treatment of Hypercoagulability in Patients with Malignant Tumor

作　　者：冷玉玲[1] 曾永蕾[1] 吴勇[1] 奚玉红 周先阳 夏克春 徐珩 郝婉蓉 LENG Yu-ling;ZENG Yong-lei;WU Yong;XI Yu-hong;ZHOU Xian-yang;XIA Ke-chun;XU Hang;HAO Wan-rong(Department of Oncology,The Second Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230061,China;Graduate School of Anhui University of Chinese Medicine,Anhui Hefei 230012,China)

机构地区：[1]安徽中医药大学第二附属医院肿瘤科,安徽合肥230061 [2]安徽中医药大学研究生院,安徽合肥230012

出　　处：《安徽中医药大学学报》2018年第2期46-49,共4页Journal of Anhui University of Chinese Medicine

基　　金：安徽中医药大学青年基金项目(2015qn039)

摘　　要：目的观察针刺治疗对恶性肿瘤患者高凝状态及血瘀证的疗效。方法将60例恶性肿瘤高凝状态患者按随机数字表法分为对照组和实验组,每组30例,两组均予常规基础治疗,实验组加予针刺治疗,对照组加予低分子肝素4 100U皮下注射治疗。观察两组患者治疗前后活化部分凝血酶原时间(activated partial thromboplastin time,APTT)、凝血酶原时间(prothrombin time,PT)和纤维蛋白原(fibrinogen,FIB)、D-二聚体(D-dimer,D-D)、血小板(platelet,PLT)水平,以及血瘀证疗效及出血性不良反应。结果两组治疗后APTT、PT较治疗前明显延长,FIB、PLT、D-D较治疗前明显降低,差异均具有统计学意义(P<0.05);两组各检测指标差值比较,差异均无统计学意义(P>0.05)。两组患者血瘀证疗效分布比较,差异具有统计学意义(P<0.05)。实验组出血性不良反应发生率显著低于对照组(P<0.05)。结论针刺治疗可以防治恶性肿瘤患者高凝状态,改善患者中医血瘀证候,且无不良反应。Objective To investigate the clinical effect of acupuncture in the treatment of hypercoagulability and blood stasis syndrome in patients with malignant tumor.Methods A total of 60 patients with malignant tumor and hypercoagulability were divided into control group and experimental group using a random number table,with 30 patients in each group.Both groups were given routine basic treatment;the patients in the experimental group were given acupuncture,and those in the control group were given subcutaneously injected low-molecular-weight heparin 4 100 U.The two groups were compared in terms of activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FIB),D-dimer(D-D),and platelet count(PLT)before and after treatment,as well as the outcome of blood stasis syndrome and adverse events.Results Both groups had significant increases in APTT and PT and significant reductions in FIB,PLT,and D-D after treatment(P<0.05),and there were no significant differences in these indices between the two groups(P>0.05).There was a significant difference in the distribution of clinical outcomes of blood stasis syndrome(P<0.05).The experimental group had a significantly lower incidence rate of adverse events than the control group(P<0.05).Conclusion Acupuncture can prevent and treat hypercoagulability in patients with malignant tumor and improve blood stasis syndrome,with few adverse events.

关 键 词：恶性肿瘤 高凝状态 针刺 低分子肝素钙 

分 类 号：R73[医药卫生—肿瘤]