初发急性白血病患者骨髓乳腺癌耐药蛋白基因表达及其与预后关系的研究  

Prognostic significance of breast cancer resistance protein in primary acute leukemia patients

作　　者：刘劲[1] 李薇[2] 段华新[1] 罗科玲[2] 周煦[3] Jin Liu;Wei Li;Hua-xin Duan;Ke-ling Luo;Xu Zhou(Department of Oncology,Hunan Province People’s Hospital,Changsha,Hunan 410002,China;Department of Hematology,Hunan Province People’s Hospital,Changsha,Hunan 410002,China;Department of Intense Care Unit,Hunan Province People’s Hospital,Changsha,Hunan 410005,China)

机构地区：[1]湖南省人民医院肿瘤科,湖南长沙410005 [2]湖南省人民医院血液科,湖南长沙410005 [3]湖南省人民医院重症医学科,湖南长沙410005

出　　处：《中国现代医学杂志》2018年第12期49-52,共4页China Journal of Modern Medicine

摘　　要：目的研究初发急性白血病患者骨髓乳腺癌耐药蛋白(BCRP)基因表达及其与预后关系的相关性。方法选取2014年1月-2014年12月入住该院血液内科的急性白血病患者67例,同时选择50例健康志愿者作为对照组。通过实时荧光定量PCR检测骨髓BCRP基因表达,并分析比较骨髓BCRP基因表达和临床预后的关系。结果急性白血病患者骨髓BCRP基因表达高于对照组(P<0.01),按照BCRP均值(3.0)将患者分为BCRP高表达组和BCRP低表达组。BCRP高表达组患者初始WBC计数较BCRP低表达组高(P<0.01),且两组生存分析比较差异有统计学意义(Log-rank=21.78,P<0.05)。结论急性白血病患者骨髓BCRP基因表达高于健康志愿者,且BCRP高表达患者的预后更差。Objective To investigate the gene expression of breast cancer resistance protein(BCRP)in bone marrow of acute leukemia(AL)and its prognosis.Methods A total of 67 AL patients admitted in our hospital from January 2014 to December 2014 were enrolled in the study,and 10 healthy volunteers were involved as control group.Real-time PCR was utilized to measure the gene expression of BCRP in bone marrow.And the difference in the BCRP gene expression and its prognosis were analyzed.Results The gene expression of BCRP in bone marrow of AL patients was statistically higher than that in the healthy volunteer group(P<0.01).Acute leukemia patients were divided into high BCRP group and low BCRP group according to the mean of BCRP(3.0).Compared with low BCRP group,the primary WBC count was higher in BCRP high group(P<0.01).The survival analysis between the two groups was statistically significant(Log-rank=21.78,P<0.05).Conclusion The gene expression of BCRP in bone marrow of AL patients was statistically increased and associated with the prognosis.High BCRP gene expression was a risk factor for poor prognosis in patients with AL.

关 键 词：急性白血病 乳腺癌耐药蛋白 基因表达 预后 

分 类 号：R733.7[医药卫生—肿瘤]