一个基于2-(4-二羟基硼烷)苯基喹啉-4-羧酸的长波长水溶性荧光探针  

A long-wavelength 2-(4-dihydroxyborane) phenyl quinoline-4-carboxylic acid derived bisboronic acid fluorescent sensor

作　　者：王浩[1,2,3,4] 方桂迁 方浩[5] 吴忠玉 姚庆强[1,2,3,4] WANG Hao;FANG Guiqian;FANG Hao;WU Zhongyu;AO Qingqiang(School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200,Shandong,China;Institute of Materia Medica,Shandong Academy of Medical Sciences,Jinan 250062,Shandong,China;Key Laboratory for Biotech-Drugs Ministry of Health,Jinan 250062,Shandong,China;Key Laboratory for Rare&Uncommon Diseases of Shandong Province,Jinan 250062,Shandong,China;Institute of Medicinal Chemistry Shandong University Jinan 250012 Shandong China)

机构地区：[1]济南大学山东省医学科学院医学与生命科学学院,山东济南250200 [2]山东省医学科学院药物研究所,山东济南250062 [3]国家卫生部生物技术药物重点实验室,山东济南250062 [4]山东省罕少见病重点实验室,山东济南250062 [5]山东大学药物化学研究所,山东济南250012

出　　处：《化学研究》2018年第2期160-164,共5页Chemical Research

基　　金：山东省自然科学基金资助项目(ZR2014YL035);2014年度留学人员科技活动项目择优资助项目;济南大学教研项目(J1447);山东省医学科学院医药卫生科技创新工程

摘　　要：水溶性荧光探针2-(4-二羟基硼烷)苯基喹啉-4-羧酸(PBAQA)能实现儿茶酚的选择性识别,但发射波长较短.PBAQA及衍生物通常在285 nm进行荧光发射.本文报道以PBAQA为building block,通过化学合成制备一个新的二硼酸荧光探针.该化合物具有更长的发射波长,发射波长为364 nm.初步荧光活性测试结果表明,该化合物对多巴胺具有一定结合选择性.对寻找具有较长发射波长的硼酸荧光探针,实现探针分子在嗜铬细胞瘤等细胞组织进行荧光成像具有重要意义.As a water-soluble fluorescent sensor,2-(4-dihydroxyborane)phenyl quinoline-4-carboxylic acid(PBAQA)can achieve selective identification of catechols,but the fluorescence emission wavelength is shorter.PBAQA and derivatives are usually emitted at 285 nm.Using PBAQA as building block,we synthesized a new diboronic acid fluorescent sensor,with a higher emission wavelength up to 364 nm.The preliminary fluorescence test showed that this compound selectively bind with dopamine.It has great significance to develop the fluorescence probe having long emission wavelength and realize the fluorescence imaging of the probe molecule in the cell and tumor such as pheochromocytoma.

关 键 词：硼酸类化合物 长波长 荧光探针 合成 

分 类 号：O627[理学—有机化学]