基于β-环糊精与偶氮苯衍生物的超分子囊泡体系的构筑  

The construction of supramolecular vesicle system based on β-CD and azobenzene derivatives

作　　者：娄凌云 苗康华 杜光焰 LOU Lingyun;MIAO Kanghua;DU Guangyan(College of Chemistry and Chemical Engineering,Southwest Petroleum University,Chengdu 6105002,Sichuan,China;College of Chemistry and Chemical Engineering,Northwestern University,Xi an 710069,Shaanxi,China)

机构地区：[1]西南石油大学化学化工学院,四川成都610500 [2]西北大学化学化工学院,陕西西安710069

出　　处：《化学研究》2018年第2期182-188,共7页Chemical Research

基　　金：苏里格研究中心与西南石油大学联合科研项目(CQYTSLGYJZX-2015-JS-1953)

摘　　要：运用铜催化的叠氮-炔基Husigen-Click环加成反应,首先设计合成了具有环糊精与三联吡啶基团的化合物A,使其同时具有了主客体识别位点和金属—离子配位位点,接着合成了具有烷基链的偶氮苯衍生物B,通过自组装,化合物A与B形成超分子聚集体.在A与B物质的量之比为1∶1时,其在H2O与四氢呋喃(THF)混合溶剂中可自组装形成具有双层膜结构的囊泡,并观察了囊泡在室温下的稳定性.可以通过调节紫外/可见光照控制该囊泡体系的结构,通过加入Fe2+使囊泡解组装.此外,我们通过Job's曲线证明A与B进行了1∶1包合,通过紫外滴定法表明加入Fe2+后的体系中,A与Fe2+离子的配位比为2∶1.We first synthesized host compound A possessing cyclodextrin and terpyridine simultaneously,which had host-guest recognition site and metal iron coordination site according to Copper-Catalyzed Azide-Alkyne Cycloaddition.Second,azobenzene derivative B equipped with alkyl chain was synthesized.Compound A and B could self-assemble and vesiculate into double layer membranes in H 2 O and THF mixtures at mole ratio of 1∶1.In the meantime,we conducted stability analysis in room temperature.Vesicle structures could be controlled by adjusting UV/Vis light and disassembly of vesicles occurred after adding Fe 2+.In addition,we demonstrated that inclusion ratio of inclusion complex A and B was 1∶1 according to job s plot and complex ratio of complex compound Fe 2+and A was 1∶2 according to UV spectrum titration.

关 键 词：Β-环糊精 CLICK反应 偶氮苯 自组装 

分 类 号：O621.1[理学—有机化学]