槐耳颗粒联合新辅助化疗对乳腺癌的疗效及对P53 Ki-67 MMP-2 MMP-9水平的影响  

Effect of Huaier Granule Combined with Neoadjuvant Chemotherapy for Breast Cancer and Its Influence on P53 Ki-67 MMP-2 and MMP-9 Levels

作　　者：单昌友 刁岩[1] 黄珊[1] 贾丽君[1] 管海涛[1] 康华峰[1] 代志军[1] 张淑群[1] SHAN Changyou;DIAO Yan;HUANG Shan(The Second Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710004,China)

机构地区：[1]西安交通大学第二附属医院肿瘤科,陕西西安710004

出　　处：《河北医学》2018年第4期579-583,共5页Hebei Medicine

基　　金：陕西省自然科学基金项目;(编号:2005CD061)

摘　　要：目的:探讨槐耳颗粒联合新辅助化疗对乳腺癌的疗效及对P53基因(P53)、Ki-67抗原(Ki-67)、基质金属蛋白酶(MMP)-2、MMP-9的影响。方法:选择2011年3月至2013年3月我院接诊的92例乳腺癌患者,通过简单随机数表法分为观察组(n=46)和对照组(n=46)。对照组采用新辅助化疗方案(吡柔比星+紫杉醇静脉注射),观察组在此基础上加用槐耳颗粒治疗,均以3周为1个疗程,连续治疗6个疗程。比较两组治疗前后乳腺癌组织P53、Ki-67的阳性表达率及血清MMP-2、MMP-9水平的变化,临床疗效、并发症的发生情况及随访3年的生存率。结果:治疗后,观察组P53阳性表达率明显升高,且显著高于对照组,Ki-67阳性表达率明显降低,且显著低于对照组(P<0.05)。治疗后,两组血清MMP-2、MMP-9水平均明显低于治疗前(P<0.05),观察组血清MMP-2、MMP-9水平明显比对照组低(P<0.05)。治疗后,观察组临床总缓解率明显高于对照组(P<0.05),胃肠道反应、骨髓抑制、脱发、肝功能损伤等总发生率明显低于对照组(P<0.05);随访过程中,观察组失访4例,对照组失访5例,观察组3年内生存率均明显高于对照组(P<0.05)。结论:槐耳颗粒联合新辅助化疗治疗乳腺癌患者的近远期疗效显著,且安全性更高,可能与调节P53、Ki67、MMP-2、MMP-9水平密切相关。Objective:To study the curative efficacy of huaier granule combined with neoadjuvant chemotherapy on the breast cancer and the serum levels of P53 gene(P53),Ki-67 antigen(Ki-67),matrix metalloproteinase(MMP)-2 and matrix metalloproteinase(MMP-9).Methods:92 patients with breast cancer admitted in our hospital from March 2011 to March 2013 were selected and randomly divided into the observation group(n=46)and the control group(n=46).The patients in control group were treated with neoadjuvant chemotherapy(pirarubicin+paclitaxel intravenous injection),while the patients in observation group were treated with huaier granule.Then the positive expression rate of P53 and Ki-67,changes of MMP-2 and MMP-9,clinical efficacy,survival rate and complications in the two groups were observed and compared before and after treatment.Results:After treatment,the positive expression rate of P53 in the observation group was significantly increased,and the positive rate of Ki-67 was significantly decreased(P<0.05),the serum levels of MMP-2 and MMP-9 of both groups were significantly lower than those before treatment and the MMP-2 and MMP-9 in the observation group were significantly lower than those of the control group(P<0.05).The clinical efficacy of observation group was significantly higher than that of the control group(P<0.05).The incidence rate of gastrointestinal reaction,myelosuppression,alopecia and liver function injury of observation group was significantly lower than that of the control group(P<0.05);during the follow-up period,4 cases were lost in the observation group and 5 cases were lost in the control group,the survival rate in the observation group in 3 years was significantly higher than that of the control group.(P<0.05).Conclusion:Huaier granule combined with neoadjuvant chemotherapy had better clinical efficacy on breast cancer,which could effectively reduce the side effects and improve the prognosis,its may be closely related to the regulation of P53,Ki67,MMP-2,and MMP-9 levels.

关 键 词：乳腺癌 槐耳颗粒 新辅助化疗 基质金属蛋白酶 

分 类 号：R737.9[医药卫生—肿瘤]