FSTL1在急性冠脉综合征患者血清中的表达水平及临床意义  

Expression level and clinical significance of FSTL1 in serum of patients with acute coronary syndrome

作　　者：陈特[1] 毕小云[1] 徐华建[1] 侯玉磊[1] 谌海兰[1] 李德涛[1] 张莉萍[1] 吴燕[2] CHEN Te;BI Xiaoyun;XU Huajian;HOU Yulei;SHEN Hailan;LI Detao;ZHANG Liping;Wu Yan(Department of Medical Clinical Laboratory,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Blood Transfusion,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院医学检验科,重庆400016 [2]重庆医科大学附属第一医院输血科,重庆400016

出　　处：《国际检验医学杂志》2018年第8期942-946,共5页International Journal of Laboratory Medicine

摘　　要：目的观察卵泡抑素样蛋白-1(FSTL1)在不同类型的急性冠状动脉综合征(ACS)患者血清中的水平变化及其临床诊断价值。方法收集临床确诊的ACS患者(ACS组)98例,分为ST段抬高型心肌梗死组(STEMI组)34例、非ST段抬高型心肌梗死组(NSTEMI组)28例、不稳定心绞痛组(UA组)36例,同时选取冠状动脉造影结果阴性的患者20例作为对照组。用酶联免疫吸附试验(ELISA)方法测定4组血清中FSTL1的水平,分析FSTL1与其他指标的相关性及诊断价值。结果 ACS各组血清FSTL1水平明显高于对照组,差异有统计学意义(P<0.05)。ACS组血清FSTL1水平与心肌肌钙蛋白(cTNT)、Gensini评分和超敏C反应蛋白(hs-CRP)水平成正相关,相关系数(r)分别为0.210、0.236、0.219。FSTL1诊断ACS的ROC曲线下面积(AUC)可达0.910(95%CI:0.832~0.988),但次于cTNT。FSTL1最佳界值为5.65μg/L,特异度84.2%,灵敏度77.5%。FSTL1联合cTNT和HDL对诊断ACS的效能最高,AUC=0.945(95%CI:0.909~0.981)。结论 ACS患者血清的FSTL1水平与炎性反应及冠状动脉狭窄程度存在一定的相关性,对于判断患者冠状动脉狭窄的严重程度及预后具有一定的临床价值。Objective To observe the level changes and clinical diagnostic value of follicular statin-1(FSTL1)in the serum of patients with different types of acute coronary syndrome(ACS).Methods Collected the clinical diagnosis of acute coronary syndrome patients 98 cases,which contained ST segment elevation myocardial infarction(STEMI)in 34 cases,non ST elevation myocardial infarction(NSTEMI)in 28 cases,unstable angina pectoris(UA)in 36 cases,while the examination resuLts of healthy people as a control group of 20 cases.The Venous blood was collected and the FSTL1 levels of the 4 groups were detected by ELISA.Results The levels of Serum FSTL1 in ACS group was significantly higher than that in normal control group(P<0.05).Serum FSTL1 of the ACS group were significant correlated with Gensini score,cTNT,hs-CRP(related coefficient:0.210,0.236,0.219 separately).The AUC of FSTL1 was 0.910(95%CI:0.832-0.988),which was lower than cTNT.The best cut-off value of FSTL1 as a biomarker was 5.65μg/L(specificity:84.2%and sensitivity:77.5%).Moreover the combination of FSTL1,HDL and cTNT exhibited significantly higher AUC=0.945(95%CI:0.909-0.981)than did other biomarkers alone or pair combinations.Conclusion In patients with acute coronary syndrome,serum FSTL1 levels has a positive correlation with the degree of coronary stenosis and inflammation reaction,and has certain value in the diagnosis of acute coronary syndrome.

关 键 词：卵泡抑素样蛋白-1 急性冠脉综合征 冠脉狭窄 体外诊断 

分 类 号：R446.6[医药卫生—诊断学]