PSCA rs2294008位点多态性与胃癌癌前病变关系的Meta分析  

Association between the PSCA rs2294008 polymorphisms and gastric cancer precancerous lesions: a Meta-analysis of case-control studies

作　　者：陈影影 甄玲玲 费素娟 CHEN Yingying;ZHEN Lingling;FEI Sujuan(School of Graduate,Xuzhou Medical University,Xuzhou 221000;Department of Gastroenterology,the Affiliated Hospital of Xuzhou Medical University,China)

机构地区：[1]徐州医科大学研究生院,徐州江苏221000 [2]徐州医科大学附属医院消化内科

出　　处：《胃肠病学和肝病学杂志》2018年第4期375-378,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的系统评价前列腺干细胞抗原(PSCA)rs2294008位点多态性与胃癌癌前病变是否存在相关性。方法应用计算机检索电子数据库Pub Med、Sino Med、CNKI、万方、VIP,按纳入标准搜索含有研究PSCA rs2294008多态性与胃癌癌前病变相关性的文章,并对所纳入文献进行Meta分析。结果共5篇文章纳入研究,病例组2 310例,对照组3 240例,研究表明,PSCA ra2294008等位基因模型、加性模型、共显性模型、显性模型与胃癌癌前病变的易感性有关,差异有统计学意义(T vs C:OR=1.18,95%CI:1.09~1.28,P<0.0001;TT vs CC:OR=1.46,95%CI:1.08~1.97,P=0.01;CT vs CC:OR=1.25,95%CI:1.09~1.42,P=0.0009;CT+TT vs CC:OR=1.31,95%CI:1.16~1.49,P<0.0001),隐性模型与胃癌癌前病变的易感性有关,但差异无统计学意义(TT vs CT+CC:OR=1.24,95%CI:0.93~1.66,P=0.15)。PSCA突变等位基因T增加了萎缩性胃炎的易感性,差异有统计学意义(T vs C:OR=1.24,95%CI:1.12~1.38,I2=24,P<0.0001;TT vs CC:OR=1.60,95%CI:1.28~2.01,I2=3,P<0.0001;CT vs CC:OR=1.42,95%CI:1.17~1.72,I^2=0,P=0.0004;CT+TT vs CC:OR=1.47,95%CI:1.22~1.77,I^2=0,P<0.0001;TT vs CC:OR=1.24,95%CI:1.04~1.47,I2=47,P=0.02)。结论 PSCA rs2294008位点多态性与胃癌癌前病变有相关性。Objective To systematically evaluate the relationship between prostate stem cell antigen(PSCA)rs2294008 polymorphisms and gastric cancer precancerous lesions.Methods Articles were searched according to the included standards that contained PSCA rs2294008 polymorphisms and gastric cancer precancerous lesions from PubMed,SinoMed,CNKI,WanFang and VIP.Results A total of 5 articles were included in the study,involved 5 550 individuals(2 310 in the case group,3 240 in the control group).Meta-analysis showed that the allele model,additive model,co-dominant model,dominant model of PSCA rs2294008 were related with the susceptibility of gastric cancer precancerous lesions.And the differences were statistically significant(P<0.05).The recessive model was associated with susceptibility of gastric precancerous lesions,but the difference was not statistically significant(P>0.05).PSCA risk allele T increased the susceptibility of atrophic gastritis.The difference was statistically significant(P<0.05).Conclusion PSCA rs2294008 may have an impact on the risk of susceptibility of gastric precancerous lesions.

关 键 词：前列腺干细胞抗原 胃癌前病变 位点多态性 META分析 

分 类 号：R735.2[医药卫生—肿瘤]