中毒性巨结肠发病机制及内科治疗新进展  

Progress of pathogenesis and medical treatment of toxic megacolon

作　　者：赵姣姣 王玉平[1] 周永宁[1] ZHAO Jiaojiao;WANG Yuping;ZHOU Yongning(Department of Gastroenterology,the First Hospital of Lanzhou University,the Key Laboratory for Gastrointestinal Diseases of Gansu Province,Lanzhou 730000,China)

机构地区：[1]兰州大学第一医院消化科甘肃省胃肠病重点实验室,甘肃兰州730000

出　　处：《胃肠病学和肝病学杂志》2018年第4期445-448,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家科技支撑计划(2014BAI09B00);甘肃省自然科学基金项目(1506RJZA257)

摘　　要：中毒性巨结肠(toxic megacolon,TMC)是由炎症性肠病(inflammatory bowel disease,IBD)引起的一种具有潜在致命性的并发症,目前治疗手段主要是外科手术治疗。作为内科医师,应对此类患者做到早期发现、合理内科过渡治疗、择机行结肠切除手术治疗、改善患者预后。我国很少有对TMC内科药物保守治疗及其发病机制研究的文章,本文复习相关国内外文献,就TMC的发病机制及其内科治疗新进展作一概述。Toxic megacolon(TMC)is a potentially fatal complication of inflammatory bowel disease(IBD),mainly caused by ulcerative colitis(UC).The current treatment mainly is surgery.As a internist,identifying as early as possible,reasonable medical treatment,surgical operation if necessary,improving patient outcomes should be accomplished.There are few literatures on the conservative treatment of TMC in our country.This paper reviewed relevant literature,a brief summary of the pathogenesis and treatment of TMC was summarized.

关 键 词：急性重症溃疡性结肠炎 中毒性巨结肠 发病机制 内科治疗 

分 类 号：R574.62[医药卫生—消化系统]