食管不同类型恶性肿瘤标志物的免疫组化阳性率分析  

Immunohistochemical positive rates of difference types of esophageal malignant tumor markers

作　　者：闫利娟 YAN Lijuan(Luoyang the Second Hospital of TCM,Luoyang Henan 471003,China)

机构地区：[1]洛阳市第二中医院,河南洛阳471003

出　　处：《中国民康医学》2018年第5期72-73,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:观察食管不同类型恶性肿瘤标志物的免疫组化阳性率。方法:回顾性分析50例恶性肿瘤患者的临床资料,其中小细胞癌41例,混合腺神经内分泌癌1例,低分化鳞状细胞癌5例,低分化腺鳞癌3例,均行免疫组化(Ki-67、CD-56、TTF-1、Cg A、Syn、P63、CK5/6、LCA、CK18)检测并总结。结果:Ki-67、Cg A和CK18在低分化腺鳞癌和混合型神经内分泌癌检测中的阳性率为100.00%;CD-56在混合型神经内分泌癌检测中的阳性率为100.0%;LCA在小细胞癌检测中的阳性率为100.0%;TTF-1在小细胞癌检测中的阳性率为53.66%;Syn在小细胞癌检测中的阳性率为95.12%,在低分化腺鳞癌中检测中的阳性率为100.00%;P63和CK5/6在低分化鳞状细胞癌和低分化腺鳞癌中的阳性率均为100.00%。结论:食管不同类型恶性肿瘤标志物的免疫组化阳性率各有差异,可作为临床诊断依据。Objective:To analyze immunohistochemical positive rates and characteristics of different types of esophageal malignant tumor markers.Methods:The clinical data of 50 patients with malignant tumors were retrospectively analyzed,including 41 cases of small cell carcinoma,1 case of mixed adenoneuroendocrine carcinoma,5 cases of poorly differentiated squamous cell carcinoma,and 3 cases of poorly differentiated adenosquamous carcinoma.All the patients were given the immunohistochemical analysis,and the levels of Ki-67,CD-56,TTF-1,CgA,Syn,P63,CK5/6,LCA,and CK18 were detected and summarized.Results:The positive rates of Ki-67,CgA and CK18 in the patients with poorly differentiated adenosquamous carcinoma and mixed adenoneuroendocrine carcinoma were all 100.00%;the positive rate of CD-56 in the patients with mixed adenoneuroendocrine carcinoma was 100.0%;the positive rate of TTF-1 in the patients with small cell carcinoma was 53.66%;the positive rates of Syn in the patients with small cell carcinoma and poorly differentiated adenosquamous carcinoma were 95.12%and 100.00%,respectively;and the positive rates of P63 and CK5/6 in the patients with poorly differentiated squamous cell carcinoma and poorly differentiated adenosquamous carcinoma were both 100.00%.Conclusions:The immunohistochemical positive rates of the different types of esophageal malignant tumor markers are different,and they could be used as the clinical diagnosis basis.

关 键 词：食管小细胞恶性肿瘤 标志物 阳性率 免疫组化 

分 类 号：R735.1[医药卫生—肿瘤]