首发精神分裂症精神病未治期对认知功能和社会功能的影响  

Influence of duration of untreated psychosis on cognition and social function in first-episode drug-nave schizophrenia

作　　者：周亚楠 翟金国[2] 陈敏[2] ZHOU Yanan;ZHAI Jinguo;CHEN Min(Mental health Institution,Jining medical college,hehua road,Jining 272051,China)

机构地区：[1]济宁医学院第二附属医院精神科,济宁272051 [2]济宁医学院精神卫生学院

出　　处：《中国神经精神疾病杂志》2018年第1期38-43,共6页Chinese Journal of Nervous and Mental Diseases

基　　金：山东省自然科学基金项目(编号:ZR2017LH036;ZR2012HM065);山东省医药卫生科技发展计划项目(编号:2015WS0417;2013WS0329);山东省高等学校科技计划项目(编号:J14LK56);济宁医学院教师科研扶持基金项目(编号:JY2017JS007);济宁医学院大学生科研项目(编号:JYXS2017KJ012)

摘　　要：目的探讨首发精神分裂症精神病未治期(duration of untreated psychosis,DUP)对认知功能和社会功能的影响。方法纳入首发且DUP≤2年的精神分裂症患者93例和正常对照93名。采用阳性和阴性症状量表(positive and negative symptoms scale,PANSS)评定患者的临床病理症状,Matrics公认认知成套测验(Matrics consensus cognitive battery,MCCB)评定所有被试认知功能,个人和社会功能量表(personal and social performance scale,PSP)和功能大体评定量表(global assessment function scale,GAF)评定所有被试社会功能。结果精神分裂症组在连线测验、符号编码、范围流畅性测验、Stroop色词测验、持续操作测验、空间广度、霍普金斯言语记忆测验-修订版(Hopkins verbal learning test-revised,HVLT-R)、简易视觉空间记忆测验(brief-visuospatial memory test-revised,BVMT-R)和迷宫测验方面的得分均低于对照组,且差异有统计学意义(均P<0.05)。精神分裂症组的GAF得分和PSP得分均低于对照组,差异具有统计学意义(均P<0.05)。精神分裂症患者DUP与HVLT-R2(r=-0.265,P=0.010)和BVMT-R3(r=-0.328,P=0.001)分别呈负相关,DUP与GAF(r=-0.292,P=0.005)和PSP(r=-0.397,P<0.001)得分分别呈负相关。结论首发精神分裂症患者存在社会功能和广泛的认知功能损害,且DUP越长,患者的认知功能和社会功能越差。Objective To explore the influence of duration of untreated psychosis(DUP)on cognition and social function in first-episode drug-naive schizophrenia.Methods Ninety-three first-episode drug-naive schizophrenic were enrolled as the schizophrenia group and 93 normal people served as the control group.The Positive and Negative Symptoms Scale(PANSS)were used to assess the degree of mental symptoms.The Matrics Consensus Cognitive Battery(MCCB)was used to evaluate the cognitive function.Personal and Social Performance Scale(PSP)and the Global Assessment Function Scale(GAF)were used to evaluate the social function.Result There were significant differences in scores of Trail Marking Test,Symbol Coding test,Category Fluency test,Stroop color word test,Continuous Performance Test,Spatial Span test,Brief-Visuospatial Memory Test-Revised(HVLT-R),Brief-Visuospatial Memory Test-Revised(BVMT-R)and Maze test between the schizophrenia group and the control group(all P<0.05).There were significant differences in scores of GAF and PSP between the schizophrenia group and the control group(all P<0.05).DUP was negatively related to the score of HVLT-R2(r=-0.265,P=0.010)or BVMT-R3(r=-0.328,P=0.001).DUP was negatively related to the scores of GAF score(r=-0.292,P=0.005)or PSP score(r=-0.397,P<0.001).Conclusion There are social function impairment and a wide range of cognitive function impairment in the first-episode drug-na?觙ve schizophrenic.The length of the DUP is associated with the severity of the social functional and cognitive functional impairment.

关 键 词：首发精神分裂症 精神病未治期 认知功能 社会功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]