甘枣宁颗粒治疗非酒精性脂肪肝炎的疗效观察  

Efficacy of Ganzaoning granules on the patients with nonalcoholic steatohepatitis

作　　者：张夏炎 彭浩[2,3] 汪怀周[4] 卞艳芳[1] 陆检英[5] 郑国银 ZHANG XiaYan;PENG Hao;WANG HuaiZhou;BIAN YanFang;LU JianYing;ZHENG GuoYin(Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;Faculty of Traditional Chinese Medicine,Second Military Medical University,Shanghai 200433,China;Hospital of Traditional Chinese Medicine,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;Department of Laboratory Diagnosis,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;Department of Traditional Chinese Medicine,Hefei Branch of Changhai Hospital,Second Military Medical University,Hefei 230000,China)

机构地区：[1]第二军医大学长海医院药学部,上海200433 [2]第二军医大学中医系,上海200433 [3]第二军医大学长海医院中医院,上海200433 [4]第二军医大学长海医院检验科,上海200433 [5]第二军医大学长海医院合肥分院中医科,合肥230000

出　　处：《药学服务与研究》2018年第2期123-126,共4页Pharmaceutical Care and Research

基　　金：国家科学技术支撑计划课题(2012BA141B05);国家自然科学基金面上项目(81573653);上海市进一步加快中医药事业发展三年行动计划(ZY3-CCCX-3-7002)

摘　　要：目的:观察甘枣宁颗粒治疗非酒精性脂肪肝炎(nonalcoholic steatohepatitis,NASH)的临床疗效。方法:选择2013-2016年在第二军医大学长海医院及其合肥分院就诊的NASH病人395例,给予甘枣宁颗粒12g/次,bid,连续服用6个月。观察病人治疗前后的一般情况、实验室指标、中医单项症状及肝脏B超检测结果,评价其疗效。结果:治疗前后的体质量指数(BMI)无显著性差异(P>0.05),而腹围差异有统计学意义(P<0.05)。病人的主要中医症状得到明显改善,总体有效率达83.29%。血脂中总胆固醇、三酰甘油和低密度脂蛋白胆固醇均较治疗前有所降低,但高密度脂蛋白胆固醇治疗前后无明显变化。治疗前病人的B超检测结果以中度NASH为主,有252例(63.80%),治疗后以轻度NASH为主,有311例(78.73%)。结论:甘枣宁颗粒治疗NASH效果明显。Objective:To observe the clinical efficacy of Ganzaoning granules on the patients with nonalcoholic steatohepa-titis(NASH).Methods:Totally,395 patients with NASH who sought medical care in Changhai Hospital,Second Military Medical University and Hefei Branch of Changhai Hospital from 2013 to 2016 were enrolled for the study.The patients were given Ganzaoning granules at a dosage of 15 g,twice a day,for a succession of 6 months.Close observations were made on the general conditions laboratory indicators single symptom of traditional Chinese medicine(TCM)as well as ultrasonographic detection results for the evaluation of treatment efficacy.Results:There were no significant differences in body mass index(BMI)before and after treatment(P〉0.05),while there was statistical significance in abdominal circumference(PC0.05).The main single symptoms of TCM were obviously improved,with an overall effective rate of 83.29%.The levels of TC,TG,and LDL-C were all reduced after the treatment,while there were no significant changes in the level of HDL-C,when compari-sons were made between pre-treatment and post-treatment.Before treatment,the patients were assessed as moderate NASH by ultrasonography,with a total of 252 cases,accounting for 63.80%.However,after treatment,they were mainly diagnosed as mild NASH,with a total of 311 cases,accounting for 78.73%.Conclusion:Ganzaoning granules could produce obvious effects on NASH.

关 键 词：甘枣宁颗粒 脂肪肝炎 非酒精性 疗效 

分 类 号：R575.1[医药卫生—消化系统] R965[医药卫生—内科学]