尼妥珠单抗联合顺铂及氟尿嘧啶治疗晚期鼻咽癌的效果  

Effect of Nimotuzumab combined with Cisplatin and Fluorouracil in the treatment of advanced nasopharyngeal carcinoma

作　　者：吴志瑛 舒禹先[2] WU Zhi-ying;SHU Yu-xian(Departnent of Oncological Radinotherapy,Nanchang 334 Hospital,Jiangxi Province,Nanchang 330024,China;Departnent of Radinotherapy,Jiangxi Cancer Hospital,Jiangxi Province,Nanchang 330029,China)

机构地区：[1]南昌三三四医院肿瘤放疗科,江西南昌330024 [2]江西省肿瘤医院放疗科,江西南昌330029

出　　处：《中国当代医药》2018年第10期137-139,共3页China Modern Medicine

基　　金：江西省卫生厅科技计划项目(20133112)

摘　　要：目的探讨尼妥珠单抗联合顺铂及氟尿嘧啶治疗晚期鼻咽癌的效果。方法选取2012年1月~2014年1月于江西省肿瘤医院就诊的50例晚期鼻咽癌患者作为研究对象,按照随机抽签法将患者分为对照组和观察组,每组各25例。对照组患者给予顺铂及氟尿嘧啶化疗,观察组患者给予顺铂及氟尿嘧啶联合尼妥珠单抗化疗。随访2年后,比较两组患者的临床疗效。结果观察组患者的2年生存率(88.0%)显著高于对照组(60.0%),差异有统计学意义(P<0.05)。观察组患者的QOL改善率高于对照组,差异有统计学意义(P<0.05)。结论临床上给予晚期鼻咽癌患者尼妥珠单抗联合顺铂及氟尿嘧啶化疗,可延长患者的生存时间,改善生活质量,值得临床推广。Objective To investigate the effect of Nimotuzumab combined with Cisplatin and Fluorouracil in the treatment of advanced nasopharyngeal carcinoma.Methods A total of 50 patients with advanced nasopharyngeal carcinoma treated in Jiangxi Cancer Hospital from January 2014 to January 2012 were selected as subjects and divided into control group and the observation group by random lottery method,25 cases in each group.The control group received chemotherapy with Cisplatin and Fluorouracil.The observation group was treated with Cisplatin and Fluorouracil combined with Nitozumab chemotherapy.After 2 years follow-up,the clinical efficacy of the two groups was compared.Results The 2-year survival rate of the patients in the observation group was 88.0%,which was significantly higher than that in the control group(60.0%),and the difference was significant(P<0.05).The QOL improvement rate of patients in the observation group was higher than that in the control group,and the difference was significant(P<0.05).Conclusion Combined with Cisplatin and Fluorouracil in patients with advanced nasopharyngeal carcinoma,the survival time of patients can be prolonged and the quality of their life can be improved.It is worthy of clinical popularization.

关 键 词：晚期鼻咽癌 尼妥珠单抗 顺铂及氟尿嘧啶 化疗 效果 

分 类 号：R739.6[医药卫生—肿瘤]