急性脑梗死患者血清Hcy、UA和CRP水平变化及与颈动脉粥样硬化的关系  

The changes of serum levels of Hcy,UA and CRP in patients with acute cerebral infarction and their correlation with carotid atherosclerosis

作　　者：马龙[1] 凡奇[1] 杨淼[1] 李强 邹小田 MA Long;FAN Qi;YANG Miao;LI Qiang;ZOU Xiaotian(People’s Hospital of Bozhou City,Anhui,Bozhou 236800,China)

机构地区：[1]安徽省亳州市人民医院,236800

出　　处：《河北医药》2018年第8期1180-1183,共4页Hebei Medical Journal

摘　　要：目的探讨急性脑梗死患者血清同型半胱氨酸(Hcy)、尿酸(UA)、C-反应蛋白(CRP)水平与变化及其与颈动脉粥样硬化的关系。方法急性脑梗死患者108例作为病例组,选取同期健康体检中心的健康体检者104例作为对照组,根据颈动脉粥样硬化斑块回声特征将急性脑梗死患者分为稳定亚组(n=67)与不稳定亚组(n=41)。并根据颈动脉粥样硬化程度将急性脑梗死患者分为Ⅰ级亚组(n=35)、Ⅱ级亚组(n=45)与Ⅲ级亚组(n=28)。采用循环酶法检测血清Hcy水平,采用酶联免疫吸附试验(ELISA)检测血清UA、CRP水平。结果病例组血清Hcy、UA、CRP水平与IMT值明显高于对照组,差异有统计学意义(P<0.05)。不稳定亚组血清Hcy、UA、CRP水平与IMT值明显高于稳定亚组,差异有统计学意义(P<0.05)。Ⅲ级组血清Hcy、UA、CRP水平与IMT值明显高于Ⅰ、Ⅱ级组,Ⅱ级组上述指标明显高于Ⅰ级组,差异均有统计学意义(P<0.05)。经Pearson相关性分析显示,急性脑梗死患者血清Hcy、UA、CRP水平与IMT值呈线性正相关(r=0.612,0.581,0.628,P<0.001)。结论急性脑梗死患者血清Hcy、UA、CRP水平均明显升高,且上述指标可能共同参与颈动脉粥样硬化斑块的形成与发展。Objective To observe the changes of serum levels of homocystine(Hcy),uric acid(UA)and C-reactive protein(CRP)in patients with acute cerebral infarction,and to explore their correlation with carotid atherosclerosis.Methods One hundred and eight patients with acute cerebral infarction who were treated in our hospital from January 2014 to January 2017 were served as case group,meanwhile,104 healthy subjects from physical examination center were served as control group.According to the echo characteristics of carotid atherosclerosis plaque,these patients were divided into stable plaque groups(n=67)and unstable plaque group(n=41).And according to carotid atherosclerosis degree,these patients were divided into gradeⅠgroups(n=35),gradeⅡgroup(n=45)and gradeⅢgroup(n=28).The serum levels of Hcy were detected by cyclophorase assay,and the serum levels of UA and CRP were detected by enzyme-linked immunosorbent assay(ELISA).Results The serum levels of Hcy,UA,CRP in case group were significantly higher than those in control group(P<0.05),and the serum levels of Hcy,UA,CRP and IMT in unstable plaque group were significantly higher than those in stable plaque group(P<0.05).And the serum levels of Hcy,UA,CRP and IMT in gradeⅢgroup were significantly higher than those in gradeⅠgroup and gradeⅡgroup,moreover,which in gradeⅡgroup were significantly higher than those in gradeⅠgroup(P<0.05).The Pearson correlation analysis showed that there was a linear positive correlation between serum levels of Hcy,UA,CRP and IMT value(r=0.612,0.581,0.612,respectively,P<0.01).Conclusion The serum levels of Hcy,UA and CRP are significantly increased in patients with acute cerebral infarction,moreover,these indexes may jointly participate in the formation and development of carotid atherosclerosis plaques.

关 键 词：急性脑梗死 同型半胱氨酸 尿酸 C-反应蛋白 颈动脉粥样硬化 

分 类 号：R743.33[医药卫生—神经病学与精神病学]