肿瘤相关成纤维细胞促肿瘤转移和放射抵抗的相关研究进展  

Research Progress of Tumor-Associated Fibroblasts Promoting Tumor Metastasis and Radiation Resistance

作　　者：毛羽驰 莫文倩 何环宇 张旭林[1] 李懿[2] MAO Yuchi;MO Wenqian;HE Huanyu;ZHANG Xulin;LI Yi(Clinical College of Kunming General Hospital of Chengdu Military Command of Kunming Medical University,Kunming 650032,China;Department of Oncology,Kunming General Hospital of Chengdu Military Command,Kunming 650032,China)

机构地区：[1]昆明医科大学成都军区昆明总医院临床学院,昆明650032 [2]成都军区昆明总医院肿瘤科,昆明650032

出　　处：《医学综述》2018年第5期895-900,共6页Medical Recapitulate

基　　金：国家自然科学基金(81572904)

摘　　要：肿瘤相关成纤维细胞(CAFs)作为肿瘤微环境中的主要细胞类型,其生物学特性具有来源、表型和功能异质性,通过产生和分泌各种趋化因子和促进上皮间充质转化,从而促肿瘤生成、增殖、侵袭和转移。CAFs可介导肿瘤干细胞支持肿瘤产生及增殖,促使肿瘤细胞放疗抵抗。CAFs还可通过旁分泌外泌体,增强肿瘤的生长和能诱导放疗抵抗。大分割放疗应用于CAFs,可诱导CAFs表达衰老表型发生变化,促肿瘤能力下降,为临床肿瘤的放疗带来新契机。Tumor-associated fibroblasts(TAFs)as the main cell types in the tumor microenvironment,with the biological characteristics of origin,phenotypic and functional heterogeneity,producing and secreting a variety of chemokines,which facilitate the epithelial-mesenchymal transition,thus promote the tumor generation,proliferation,invasion and metastasis.CAFs play a key role in mediating CSCs to support tumor genesis and proliferation and resist radiotherapy.Furthermore,CAFs can also secrete exosome,enhancing tumor growth and inducing radiotherapy resistance.The application of high-dose radiotherapy to CAFs can induce the expression of the aging phenotype in CAFs and decrease the tumor promoting ability,bringing new opportunities for the clinical radiotherapy.

关 键 词：肿瘤相关成纤维细胞 肿瘤微环境 外泌体 放射治疗 

分 类 号：R73-37[医药卫生—肿瘤] R730.55[医药卫生—临床医学]