食欲素A与神经系统相关疾病研究进展  

Research progress of the relationship between orexin-A and neurological diseases

作　　者：徐超[1] 白波[2] XU Chao;BAI Bo(Cheeloo College of Medicine,Shandong University,Jinan 250012;Insititute of Neurobiology,Jining Medical University,Jining 272067,China)

机构地区：[1]山东大学齐鲁医学部,济南250012 [2]济宁医学院神经生物研究所,济宁272067

出　　处：《济宁医学院学报》2018年第2期146-149,共4页Journal of Jining Medical University

基　　金：山东省自然科学基金资助项目(ZR2013CQ031;ZR2015CL021)

摘　　要：食欲素A是一种由下丘脑分泌的神经肽,具有诸多的生理功能。尤其在调控摄食行为、睡眠-觉醒节律、奖赏与成瘾以及能量平衡等方面具有重要的作用。近年来研究发现,食欲素A与多种神经系统相关疾病的病理生理学作用有着重要的联系。本文重点针对发作性睡病、抑郁症、缺血性脑卒中、阿尔兹海默症、神经性厌食与食欲素A关系的研究进展进行综述。Orexin-A is an important hypothalamic neuropeptide which can regulate numerous physiological functions,such as feeding behavior,sleeping awakening rhythm,reward and addiction,energy balance.Recent studies found that orexin-A has play an significant role in the pathophysiology of various neurological diseases.This article elaborates the research progress of orexin-A and several neurological diseases in latest years.

关 键 词：食欲素A 睡眠-觉醒节律 神经系统疾病 神经保护 

分 类 号：R74[医药卫生—神经病学与精神病学]