肠黏膜屏障功能障碍与细菌易位研究进展  

Research Advances of Intestinal Barrier Dysfunction and Bacterial Translocation

作　　者：葛耀植 黄红兰 GE Yaozhi;HUANG Honglan(Norman Bethune Health Science Center of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学白求恩医学部,长春130021

出　　处：《医学综述》2018年第6期1072-1076,共5页Medical Recapitulate

摘　　要：肠黏膜屏障能防止肠腔内有害物质穿过肠黏膜进入体内其他组织器官和血液循环。危重病患者常存在肠黏膜屏障功能障碍,导致肠道细菌易位,对机体造成"二次打击",可继发全身炎症反应综合征、多器官功能障碍,甚至导致患者死亡。导致肠黏膜屏障功能障碍的因素有很多,包括肠道微生态失调、肠道缺血/再灌注、内毒素、肠黏膜免疫功能受损等,积极的肠内营养支持、合理有效地应用抗生素、微生态制剂的应用等可维护肠黏膜屏障功能的完整性,减少细菌易位的发生。Intestinal barrier can prevent harmful substances from passing through the intestinal mucosa into other tissues,organs and blood circulation.Intestinal barrier dysfunction in critical illness patients may lead to bacterial translocation,cause"secondary blow"to the body,and result in secondary systemic inflammatory response syndrome,multiple-organ dysfunction,and even death.Many factors can lead to intestinal mucosal barrier dysfunction,like intestinal microecological disorder,intestinal ischemia-reperfusion,endotoxin and intestinal mucosal immune function impaire.Enteral nutrition support,rational application antibiotics and probiotics can maintain the integrity of intestinal mucosal barrier function and reduce bacterial translocation.

关 键 词：肠黏膜屏障功能障碍 细菌易位 肠黏膜屏障 肠道微生态失调 

分 类 号：R574.4[医药卫生—消化系统]