ICVD患者体内血管活性因子与血脂及抗心磷脂抗体水平的相关性  

Correlation among vasoactive factors,blood lipids and anticardiolipin antibody levels in ICVD patients

作　　者：邓勇[1] 佘笑梅 彭道勇[1] 王茂湘[1] 范铁平[1] 王晓东[1] 赵旭生[1] DENG Yong;SHE Xiao-mei;PENG Dao-yong;WANG Mao-xiang;FAN Tie-ping;WANG Xiao-dong;ZHAO Xu-sheng(Neuro-Intensive Care Unit,Central Hospital of Dalian City,Dalian,Liaoning,116033,China)

机构地区：[1]辽宁省大连市中心医院NICU,辽宁大连116033

出　　处：《心血管康复医学杂志》2018年第2期128-132,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察缺血性脑血管病(ICVD)患者血清高敏C反应蛋白(hsCRP)、白介素(IL)-6、肿瘤坏死因子(TNF)-α及肝细胞生长因子(HGF)水平,并分析其与血脂和抗心磷脂抗体(ACA)水平的相关性。方法:回顾性分析2015年3月~2016年8月在我院治疗的45例ICVD患者的临床资料,并选择同期在我院治疗的45例非ICVD患者作为非ICVD对照组。观察比较两组患者血清hsCRP、IL-6、TNF-α、HGF、血脂和ACA水平的差异,分析ICVD患者血清hsCRP、IL-6、TNF-α及HGF水平与血脂和ACA水平的相关性。结果:与非ICVD对照组比较,ICVD组血清hsCRP[(4.69±1.31)mg/L比(8.87±1.56)mg/L]、IL-6[(12.17±4.33)mg/L比(34.26±5.15)mg/L]、TNF-α[(28.45±2.18)pg/ml比(48.35±3.15)pg/ml]、HGF[(502.34±15.36)pg/ml比(876.25±18.15)pg/ml]、ACA[(4.11±0.65)IU/L比(7.89±1.02)IU/L]、总胆固醇[(4.68±1.12)mmol/L比(5.57±1.21)mmol/L]、低密度脂蛋白-胆固醇[(2.62±0.49)mmol/L比(3.24±0.87)mmol/L]和甘油三酯[(1.42±0.31)mmol/L比(1.84±0.37)mmol/L]水平均显著升高,而高密度脂蛋白-胆固醇水平[(1.28±0.25)mmol/L比(1.02±0.22)mmol/L]显著降低,P均=0.001。Pearson相关分析显示,ICVD患者的血清hsCRP、IL-6、TNF-α、HGF水平与血清ACA、TC、LDL-C和TG水平呈显著正相关(r=0.468~0.632,P<0.05或<0.01),与HDL-C水平呈显著负相关(r=-0.571^-0.511,P<0.05或<0.01)。结论:ICVD患者血清hsCRP、IL-6、TNF-α及HGF水平显著升高,且与血脂、ACA水平密切相关,可作为临床监测ICVD的重要指标。Objective:To observe serum levels of high sensitive C reactive protein(hsCRP),interleukin(IL)-6,tumor necrosis factor(TNF)-αand hepatocyte growth factor(HGF)in patients with ischemic cerebrovascular disease(ICVD),and analyze their correlation with blood lipids and anticardiolipin antibody(ACA)levels.Methods:A total of 45 ICVD patients treated in our hospital from Mar 2015 to Aug 2016 were regarded as ICVD group.Another 45 non-ICVD patients treated in our hospital during the same period were regarded as non-ICVD control group.Serum levels of hsCRP,IL-6,TNF-α,HGF,blood lipids and ACA were observed and compared between two groups,and correlation among serum levels of hsCRP,IL-6,TNF-αand HGF,blood lipids and ACA levels were analyzed in ICVD patients.Results:Compared with non-ICVD control group,there were significant rise in serum levels of hsCRP[(4.69±1.31)mg/L vs.(8.87±1.56)mg/L],IL-6[(12.17±4.33)mg/L vs.(34.26±5.15)mg/L],TNF-α[(28.45±2.18)pg/ml vs.(48.35±3.15)pg/ml],HGF[(502.34±15.36)pg/ml vs.(876.25±18.15)pg/ml],ACA[(4.11±0.65)IU/L vs.(7.89±1.02)IU/L],total cholesterol[(4.68±1.12)mmol/L vs.(5.57±1.21)mmol/L],low density lipoprotein cholesterol[(2.62±0.49)mmol/L vs.(3.24±0.87)mmol/L]and triglyceride[(1.42±0.31)mmol/L vs.(1.84±0.37)mmol/L],and significant reduction in serum level of high density lipoprotein cholesterol[(1.28±0.25)mmol/L vs.(1.02±0.22)mmol/L]in ICVD group,P=0.001 all.Pearson correlation analysis indicated that serum levels of hsCRP,IL-6,TNF-αand HGF were significant positively correlated with serum levels of ACA,TC,LDL-C and TG(r=0.468~0.632,P<0.05 or<0.01),and significant inversely correlated with HDL-C level(r=-0.571^-0.511,P<0.05 or<0.01)in ICVD patients.Conclusion:Serum levels of hsCRP,IL-6,TNF-αand HGF significantly rise in ICVD patients,and they are closely correlated with levels of blood lipids and ACA,which can serve as important indexes monitoring ICVD.

关 键 词：脑缺血 炎症 肝细胞生长因子 

分 类 号：R743.3109[医药卫生—神经病学与精神病学]