恶性肿瘤与阻塞性睡眠呼吸暂停低通气综合征关系的临床分析  

Clinical relationship between malignant tumor and obstructive sleep apnea hypopnea syndrome

作　　者：吴铁鹰[1] 曹晶杰[1] 刘永兰[2] 黄玉胜 张峻青[1] 冯燕国[1] 张改英 任燕梅 Wu Tieying;Cao Jingjie;Liu Yonglan;Huang Yusheng;Zhang Junqing;Feng Yanguo;Zhang Gaiying;Ren Yanmei(Cancer Center,the 264th Hospital of PLA China,Taiyuan 030001,China)

机构地区：[1]中国人民解放军264中心医院肿瘤中心,太原030001 [2]中国人民解放军264中心医院统计室,太原030001

出　　处：《山西医药杂志》2018年第7期738-741,共4页Shanxi Medical Journal

基　　金：全军保健专项基金(13BJZ04)

摘　　要：目的探讨恶性肿瘤与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的临床关系,以提高恶性肿瘤与OSAHS关联性的认识。方法对2016年3月至12月100例初诊为恶性肿瘤患者(肿瘤组)100例及非恶性肿瘤组(对照组)100例行打鼾史、嗜睡评价量表(ESS)评分比较及脉搏血氧监测系统分析。检测最低脉搏容积血氧饱和度(LSpO2)、氧减<90%的时间(T90%,min)、血氧饱和度<90%的时间占总监测时间百分比(TS90,%)。结果打鼾史肿瘤组(18±9)年、对照组(8±6)年;ESS评分肿瘤组:14.7±3.3、对照组:9.6±2.7;恶性肿瘤组LSpO2为(23±13)%、T90%为(268±114)min、TS90为(55±26)%;对照组:LSpO2为(58±15)%、T90%为(109±100)min、TS90为(23±25)%。治疗组与对照组相比差异有统计学意义(P<0.01)。OSAHS病情分度:恶性肿瘤组:重度42例、中度46例、轻度12例;对照组:重度16例、中度53例、轻度31例,2组比较差异具有统计学意义(χ2=20.545,P<0.01)。结论恶性肿瘤患者与OSAHS患者有较高的关联性,OSAHS增加恶性肿瘤发病率的风险,积极提前解除OSAHS可能降低恶性肿瘤的发生。Objective To study the clinical relationship between malignant tumor and obstructive sleep apnea hypopnea syndrome(OSAHS),and to raise the awareness of relationship between OSAHS and tumorigenesis.Methods One hundred patients(cancer group)primarily diagnosed malignant tumor and 100 control patients from March 2016 to December 2016 were recruited.The history of snoring and Epworth Sleepiness Scale(ESS)were analyzed.The lowest oxygen saturation(LSpO 2),total time spent with oxygen saturation below 90%(T90%)and the total oxygen saturation below 90%monitoring time(TS90%)were detected.Results In cancer group,the history of snoring was(18±9)years,while in control group was(8±6)years.The ESS was(14.7±3.3)in cancer group,while in control group was(9.6±2.7).The LSpO 2,T90%and TS90 in cancer group were(23±13)%,(268±114)min and(55±26)%respectively,while in control group,the LSpO 2,T90%and TS90 were(58±15)%,(109±100)min and(23±25)%,respectively.The differences were statistically significant(P<0.01).The degrees of OSAHS in cancer group were 42 cases with severe,46 with moderate and 12 with mild OSAHS.In control group,those were 16 with severe,53 with moderate and 31 with mild OSAHS.There were difference between Two groups significantly(χ2=20.545,P<0.01).Conclusion Patients with malignant tumor have a closely relationship with OSAHS.OSAHS patients may have higher malignant tumor morbidity.Positively treatment of OSAHS could decrease cancer incidence.

关 键 词：睡眠呼吸暂停 阻塞性 肿瘤 危险因素 

分 类 号：R730.5[医药卫生—肿瘤] R766[医药卫生—临床医学]