硫氧还蛋白还原酶2在恶性肿瘤中的研究进展  

Research progress of thioredoxin reductase 2 in malignant tumor

作　　者：吴逸飞 刘宝刚[1] WU Yifei;LIU Baogang(Harbin Medical University Cancer Hospital,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨150081

出　　处：《实用肿瘤学杂志》2018年第2期174-178,共5页Practical Oncology Journal

摘　　要：硫氧还蛋白还原酶(TrxR)是广泛分布于生物体内的抗氧化系统家族成员,主要作用是对酶和转录因子以及细胞水平的氧化还原状态的调节,参与细胞的生长、增殖和凋亡,同时也为恶性肿瘤的发生和进展创造了有利条件。TrxR共有三种同工酶,其中TrxR2主要分布于线粒体中,最近研究发现TrxR2在多种恶性肿瘤组织中表达上调,且表达情况远高于癌旁正常组织。另外,TrxR2的表达与多种恶性肿瘤患者的临床病理特征及其生存预后存在相关性。推测TrxR2可能参与恶性肿瘤的发生、发展和转移,本文将对TrxR2在几种恶性肿瘤中的研究进展进行综述,以探究TrxR2是否能成为恶性肿瘤的生物学标志物,并作为肿瘤治疗的新靶点。Thioredoxin reductase(TrxR),a family of antioxidant family member,is widely distributed in the body.Its main function is to regulate the redox status of enzymes and transcription factors at the cellular level,and to participate in cell growth,proliferation and apoptosis.Meanwhile,it also provides favorable conditions for the occurrence and deterioration of malignant tumors.TrxR has three kinds of isoenzymes.TrxR2 distributed in mitochondria is also up-regulated in most malignant tumors and its expression is much higher than that in paracancerous tissues and normal tissues in recent studies.In addition,there is a lot of correlation between the up-regulated expression of TrxR2 and clinicopathological features as well as prognosis of many malignant tumors.It is speculated that TrxR2 may be involved in the occurrence,deterioration and metastasis in malignant tumors.This article reviews the progress of TrxR2 in several malignancies to explore whether or not TrxR2 can be a biomarker of malignancy and serve as a novel target for oncology treatment.

关 键 词：硫氧还蛋白 硫氧还蛋白还原酶2 恶性肿瘤 

分 类 号：R73[医药卫生—肿瘤]