肠道菌群与阿尔茨海默病的关系  

Relationship between gut microbiota and Alzheimer′s disease

作　　者：王妍妍[1] 李建英 韩柏[1,2] Wang Yanyan;Li Jianying;Han Bai(Department of Psychiatry,the First Hospital/First Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China;The Institute of Dizzness,General Hospital of Chinese People′s Armed Police Forces,Beijing 100039,China)

机构地区：[1]山西医科大学第一医院精神卫生科,太原030001 [2]武警总医院眩晕病研究所,北京100039

出　　处：《中华临床医师杂志（电子版）》2018年第2期107-110,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：山西省科技攻关项目(2007031092-8);山西省回国留学人员科研资助项目(2007-13-89);中国武警总医院博士后基金(2010-42217);山西省留学回国人员科技活动择优资助(2013-68)

摘　　要：阿尔茨海默病(AD)是一种以进行性记忆丧失和精神、行为功能障碍为特征的中枢神经系统退行性疾病,它是老年痴呆最常见的类型,其发病机制至今仍未明确。肠道菌群作为共生于胃肠道生态系统的大量微生物,可通过肠道微生物-肠-脑轴这一双向交流信息系统与宿主相互作用。肠道菌群失调与肥胖、2型糖尿病以及AD的发病机制密切相关。本文的目的是总结、讨论目前的研究结果以阐述肠道菌群在AD病情发展中的作用,通过了解AD潜在的发病机制,提出新的治疗方法。Alzheimer′s disease(AD),the most common form of dementia,is a degenerative disease of the central nervous system characterized by progressive memory loss and mental and behavioral dysfunction.The pathogenesis of AD remains unclear.A large number of microorganisms reside in the human gastrointestinal ecosystem,and the gut microbiota interacts with the host through the microbiotagut-brain axis,which is a bidirectional communication system.Disorders in the gut microbiota are closely associated with the pathogenesis of obesity,type 2 diabetes mellitus,and AD.The purpose of this review is to summarize and discuss the current findings regarding the role of the gut microbiota in the development of AD.Understanding the relationship between gut microbiota and AD may provide new insights into the development of novel therapeutic strategies for AD.

关 键 词：阿尔茨海默病 肠道菌群 炎症 肥胖 2型糖尿病 

分 类 号：R749.16[医药卫生—神经病学与精神病学]