CD40-1C/T单核苷酸多态性与缺血性脑卒中易感性的研究进展  

Relationship between CD40-1C/T single nucleotide polymorphism and ischemic stroke susceptibility:a review of recent advances

作　　者：段文慧[1] 李东芳[1] 张静雯[1] 鲁涛[1] 孙震[1] Duan Wenhui;Li Dongfang;Zhang Jingwen;Lu Tao;Sun Zhen(Department of Neurology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二临床医学院神经内科,太原030001

出　　处：《中华临床医师杂志（电子版）》2018年第2期123-126,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：缺血性脑卒中发病受多种遗传和环境因素的影响。动脉粥样硬化是缺血性脑卒中的重要病理、生理基础,目前研究发现CD40/CD40配体(CD40L)系统及血清可溶性CD40配体(s CD40L)参与动脉粥样硬化等炎性反应过程进而影响缺血性脑卒中的发生、发展。而CD40-1C/T单核苷酸多态性可通过调控该系统及血清s CD40L影响缺血性脑卒中的疾病易感性。本文对CD40-1C/T单核苷酸多态性与缺血性脑卒中易感性的研究进展进行综述。The occurrence of ischemic stroke is influenced by a variety of genetic and environmental factors.Atherosclerosis is an important pathologic and physiological basis for the development of ischemic stroke.The CD40/CD40 ligand(CD40L)system and serum soluble CD40 ligand(sCD40L)are involved in inflammatory processes such as atherosclerosis,and can affect the development and progression of ischemic stroke.The single nucleotide polymorphism CD40-1C/T might contribute to susceptibility to ischemic stroke by regulating the CD40/CD40L system and the expression of sCD40L.This paper reviews the recent progress in the understanding of the association between CD40-1C/T single nucleotide polymorphism and ischemic stroke susceptibility.

关 键 词：CD40-1C/T 单核苷酸 多态性 脑卒中 缺血性 CD40/CD40L 动脉粥样硬化 

分 类 号：R743.3[医药卫生—神经病学与精神病学]