光学相干断层扫描技术在原发性开角型青光眼早期诊断中的应用  

Optical coherence tomography in diagnosis of early primary open angle glaucoma

作　　者：海鸥 郭莉 郭春霞[2] 崔志利 Ou Hai;Li Guo;Chun-Xia Guo;Zhi-Li Cui(Department of Ophthalmology,the 451th Hospital of Chinese PLA,Xi'an 710030,Shaanxi Province,China;Outpatients Department,School of Information and Navigation,Air force Engineering University,Xi'an 710077,Shaanxi Province,China;Department of Ophthalmology,Xijing Hospital,Medical University of the Air Force,Xi'an 710032,Shaanxi Province,China)

机构地区：[1]中国人民解放军第四五一医院眼科,中国陕西省西安市710077 [2]空军工程大学信息与导航学院门诊部,中国陕西省西安市710030 [3]空军军医大学西京医院眼科,中国陕西省西安市710032

出　　处：《国际眼科杂志》2018年第5期909-911,共3页International Eye Science

摘　　要：目的:探讨利用光学相干断层扫描技术(optical coherence tomography,OCT)测量视乳头旁视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度、视盘形态和黄斑区视网膜厚度在原发性开角型青光眼(primary open angle glaucoma,POAG)早期诊断中的应用价值。方法:选取2016-01/2017-06本院收治的POAG患者65例85眼作为研究组,随机选取同期在本院进行身体检查的健康者52例78眼作为对照组,采用OCT测量视乳头旁RNFL厚度、黄斑区视网膜厚度和视盘参数包括杯/盘比(C/D)、视杯面积(cup area,CA)、视杯容积(cup volume,CV)、视盘面积(disc area,DA)、盘沿面积(rim area,RA)和盘沿容积(rim volume,RV),并对检测结果进行比较分析。结果:研究组视乳头旁RNFL厚度在上方、下方、颞侧、鼻侧和均值均明显小于对照组,差异有统计学意义(P<0.001);研究组CA、CV、C/D明显高于正常对照组,差异有统计学意义(P<0.001),而DA、RV明显小于正常对照组,差异有统计学意义(P<0.001),DA则略小于正常对照组,差异无统计学意义(P>0.05)。研究组黄斑区视网膜厚度在上方、下方、颞侧、鼻侧均明显小于对照组,差异有统计学意义(P<0.001)。结论:OCT能够定量客观检测RNFL厚度、黄斑区视网膜厚度和视盘参数,这有助于POAG的早期诊断。AIM:To evaluate the clinical value of retinal nerve fiber layer(RNFL)thickness,optic disc parameters and macular thickness by optical coherence tomography(OCT)in early diagnosis of primary open angle glaucoma(POAG).METHODS:Sixty-five patients(eighty-five eyes)were selected as a study group and fifty-two normal people(seventy-eight eyes)were selected as a control group.The retinal nerve fiber layer thickness,optic disc parameters,including cup/disc(C/D)rate,cup area(CA),cup volume(CV),disc area(DA),rim area(RA)and rim volume(RV),and macular thickness were detected by Cirrus HD-OCT.The data were compared and analyzed.RESULTS:The retinal nerve fiber layer thickness of superior,inferior,temple,nasal and average in the study group were all significantly thinner than those of the control group(P<0.001).The cup area,cup volume and cup/disc ratio in the study group were significantly higher than those of the control group(P<0.001);while the rim area and rim volume in the study group were significantly lower than those of the control group(P<0.001).But the disc area was not significantly different between two groups(P>0.05).The macular thickness of superior,inferior,temple and nasal in the study group were all significantly thinner than those of the control group(P<0.001).CONCLUSION:OCT can detect the change of retinal nerve fiber layer thickness,optic disc parameters and macular thickness,it is helpful for early diagnosis of POAG.

关 键 词：光学相干断层扫描成像术 原发性开角型青光眼 视网膜神经纤维层厚度 视盘参数 黄斑区视网膜厚度 

分 类 号：R775[医药卫生—眼科]