自偶联法合成4,4’-二乙酰基联苯  

Synthesis of 4,4 '-Diacetylbiphenyl by Homocoupling Reaction

作　　者：江潘利 熊思文 申秀丽 郭孟萍[1] JIANG Pan-li;XIONG Si-wen;SHEN Xiu-li;GUO Meng-ping(Institute of Coordination Catalysis,College of Chemistry and Bio-engineering, Yichun University,Yichun 336000,China)

机构地区：[1]宜春学院化学与生物工程学院,配位催化研究所,江西宜春336000

出　　处：《宜春学院学报》2018年第3期7-9,共3页Journal of Yichun University

基　　金：国家自然科学基金(No.21363026)资助

摘　　要：以对乙酰基苯硼酸的自偶联反应合成4,4’-二乙酰基联苯,采用1.0 mol%水溶性Pd Cl_2(NH_2CH_2COOH)_2为催化剂,1.0 mmol K_2CO_3为助催化剂,在i-Pr OH/H_2O(v/v=1:2)混合溶剂中,空气中常温反应12 h,目标化合物分离产率达95%。催化剂和产物经简单的相分离即可得到产物,反应后处理简单,产物易于纯化。4,4’-Diacetylbiphenyl can be synthesized by homocoupling reaction of 4-acetylphenylboronic acid with 1.0 mol%PdCl 2(NH 2CH 2COOH)2 as catalyst and 1.0 mmol K 2CO 3 as cocatalyst under air in i-PrOH/H 2O(v/v=1:2)at room temperature in 12 h.95%isolated yield of the target compound can be obtained.The separation of the product 4,4’-Diacetylbiphenyl from catalyst is more facile and the product is easy to be purified.

关 键 词：4 4’-二乙酰基联苯 水溶性PdCl 2(NH 2CH 2COOH)2 催化合成 自偶联反应 绿色化学 

分 类 号：R914.5[医药卫生—药物化学]