基于β-环糊精碳纳米片修饰电极的伏安传感器快速检测磺胺嘧啶  

Voltammetric Sensor Based on β-Cyclodextrin-Carbon Nanosheets Modified Electrode for Rapid Determination of Sulfadiazine

作　　者：韦寿莲 利健文[2] 姚夙 欧阳壮 魏承炀 WEI Shou-Lian;LI Jian-Wen;YAO Su;OUYANG Zhuang;WEI Cheng-Yang(Faculty of Environmental and Chemical Engineering,Zhaoqing University,Zhaoqing 526061,China;Guangdong Food and Drug Vocational College,Guangzhou 510620,China;Institute of Zhaoqing Quality Supervision and Inspection,Zhaoqing 526070,China)

机构地区：[1]肇庆学院环境与化学工程学院,肇庆526061 [2]广东食品药品职业学院,广州510520 [3]肇庆市质量计量监督检测所,肇庆526070

出　　处：《分析化学》2018年第5期773-779,共7页Chinese Journal of Analytical Chemistry

基　　金：广东省医学科研基金项目(No.2016369);广东食品药品职业学院科研基金项目(No.2015YZ015);肇庆市科技计划项目(No.2015B010301002)资助

摘　　要：采用超声电解的方法制备碳纳米片(CNS),通过超声分散法将β-环糊精(β-CD)负载在CNS上,再通过滴涂法将β-CD-CNS纳米复合材料固载在玻碳电极表面,构建磺胺嘧啶(SD)伏安传感器。以差分脉冲溶出伏安法(DPSV)研究SD传感器的电催化性能,考察和优化了p H值、修饰量、扫描速度、搅拌速度和时间、沉积电位和时间等参数的影响。结果表明,β-CD-CNS纳米复合材料在中性溶液对SD具有良好的催化活性,能显著提高SD的电流响应。在优化的条件下,SD在+0.87 V产生一个灵敏的氧化峰,氧化峰电流ip(μA)与SD的浓度在0.05~13.5μmol/L范围内呈良好的线性关系,相关系数为0.999,检出限为12.2 nmol/L(S/N=3)。本方法成功应用于水和牛奶中SD残留检测,加标回收率为80.0%~102%,RSD≤5.2%。Carbon nanosheets load beta-cyclodextrin(β-CD-CNS)as a new modified electrode materials was reported for the electrochemical determination of sulfadiazine(SD).Carbon nanosheets(CNS)were prepared by a new method of ultrasonic electrolysis in which theβ-CD was attached on CNS through ultrasonic dispersion method.Theβ-CD-CNS composite nanomaterials were immobilized onto glassy carbon electrodes with drops of coating method to construct an SD voltammetric sensor.The differential pulse stripping voltammetry(DPSV)was used to characterize the electrocatalytic behavior of the developed sensor.The Effects of some parameters on the response behavior of the sensor such as pH,modification amount,scanning rate,stirring speed,stirring time,deposition potential and time were investigated and optimized.The results indicated that theβ-CD-CNS composite nanomaterials had excellent electroactivity for the SD in neutral solution and greatly improved the current response of SD.Under the optimal conditions,the SD had an irreversible characteristic oxidation peak around+0.87 V,and the oxidation peak current ip(μA)had a good linear relationship with the concentration C(μmol/L)of the SD in concentration range of 0.05μmol/L-13.5μmol/L with correlation coefficients of 0.999.The detection limit was 12.2 nmol/L(S/N=3).The sensor was successfully applied for the trace SD determination in water and milk samples and the recoveries from the spiked samples were 80.0%-102%with RSD≤5.2%.

关 键 词：磺胺嘧啶 电化学检测 碳纳米片 Β-环糊精 差分脉冲溶出伏安法 

分 类 号：O657.1[理学—分析化学] TS252.7[理学—化学] X832[轻工技术与工程—农产品加工及贮藏工程]