组织蛋白酶S在肠易激综合征中作用的研究进展  

Advances in Study on Role of Cathepsin S in Irritable Bowel Syndrome

作　　者：王爽爽[1] 陈超英[1] 吕宾[1] 张璐[1] WANG Shuangshuang;CHEN Chaoying;Lv Bin;ZHANG Lu(Department of Gastroenterology,the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006)

机构地区：[1]浙江中医药大学附属第一医院消化内科,310006

出　　处：《胃肠病学》2018年第4期248-250,共3页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金青年项目(81600427)

摘　　要：肠易激综合征(IBS)是一类常见的功能性肠道疾病,其病因和发病机制尚未完全明确,可能与胃肠动力异常、内脏高敏感、肠道炎症、免疫功能改变、脑-肠轴功能紊乱等因素有关。组织蛋白酶S(CTSS)是广泛存在于各种细胞溶酶体内的一类蛋白水解酶,参与多种病理生理过程。近年研究证实CTSS可能参与IBS发生。本文就CTSS在IBS中作用的研究进展作一综述。Irritable bowel syndrome(IBS)is a common functional intestinal disease,and its etiology and pathogenesis are not completely clear.The pathogenesis of IBS involves disturbed gastrointestinal motility,gut hypersensitivity,intestinal inflammation,immune dysfunction and brain-gut axis abnormality.Cathepsin S(CTSS)is a proteolytic enzyme widely distributed in various cell lysosomes,and participates in a variety of pathophysiological processes.Recent studies have shown that CTSS may be involved in the pathogenesis of IBS.This article reviewed the advances in study on role of CTSS in IBS.

关 键 词：组织蛋白酶类 肠易激综合征 炎症 抗原 治疗 

分 类 号：R574[医药卫生—消化系统]