HLA-A基因多态性与新疆和田地区维吾尔族自然长寿人群的相关性研究  

Study on the correlation between HLA-A gene polymorphism and Uygur natural longevity population in Xinjiang Hetian Area

作　　者：努尔古力.乃依木 玛依拉.吾甫尔 程祖亨[1] 陈凤辉[2] 邱长春[3] NU er gu li·nai yi mu;MA yi la·wu pu er;CHENG Zu-heng;CEHN Feng-hui;QIU Chang-chun(Comprehensive Cardiology Department of the First Affiliated Hospital of Xinjiang Medical University,Xinjiang Wulumuqi 830054,China;College of nursing,Xinjiang Medical University,Xinjiang Wulumuqi 830000,China;State Key Laboratory of molecular biology,Institute of basic research Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100000,China)

机构地区：[1]新疆医科大学第一附属医院综合心脏内科,新疆乌鲁木齐830054 [2]新疆医科大学护理学院,新疆乌鲁木齐830000 [3]中国医学科学院中国协和医科大学基础研究所医学分子生物学国家重点实验室,北京100000

出　　处：《临床医药文献电子杂志》2018年第13期10-11,13,共3页Electronic Journal of Clinical Medical Literature

基　　金：国家自然科学基金(31160215)

摘　　要：目的探讨新疆和田地区自然长寿老人HLA-A基因的多态性特点与长寿的相关性。方法将在2000年~2015年纳入的新疆和田地区维吾尔族人群根据年龄分为长寿组144例,老年组93例,同时选择对照组102例。应用聚合酶链式反应-序列特异引物法(PCR-SSP)进行HLA-A座位的基因分型并进行各等位基因频率的比较。结果三组人群中HLA-A*2、HLA-A*11、HLA-A*24等位基因的检出率最高,其中长寿组HLA-A*11基因频率为0.171,高于对照组0.071,P<0.05,与老年组比较无显著差异(P>0.05)。其余各等位基因频率之间的比较无统计学意义(P均>0.05)。结论新疆和田地区维吾尔族人群中HLA-A*11基因与长寿密切相关,可能是人类长寿的有利基因。Objective To investigate the polymorphism on HLA-A locus of Xinjiang hotan natural longevous people and its assosiation with longevity.Methods The study population were enrolled from 2000to2015 in Xinjiang Hotan Uyghur People,was divided into three groups,the longevity group144,the older age group 93.the control group 102.HLA-A locus was typed with polymeras chain reaction-sequence specific primer(PCR-SSP)technique and comparative analyses were carried out among relevant alleles between the three groups.Results The Most common alleles were HLA-A*2,HLA-A*11,HLA-A*24 in the three groups.and in which,the frequency of HLA-A*11 in longevity group 0.171 were higher than control group0.071,P<0.05,but no significant difference could be found when compared older age group(P>0.05),and no difference was found in other alleles between the three groups(P>0.05 for all).Conclusion HLA-A*11 gene is strongly assosiated with longevity,it might be the favorable gene of human longevity among the Uyghur people in XinJiang Khotan.

关 键 词：人类白细胞抗原 自然长寿 基因频率 

分 类 号：R394.3[医药卫生—医学遗传学]