喉癌保留喉功能手术治疗的临床疗效和安全性  

The clinical efficacy and safety of laryngeal cancer preserving laryngeal function surgery

作　　者：刘萱[1] LIU Xuan(Tangshan workers hospital,otolaryngology department,hebei tangshan 063000,China)

机构地区：[1]唐山工人医院耳鼻喉科,河北唐山063000

出　　处：《临床医药文献电子杂志》2018年第24期3-3,5,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的探讨喉癌保留喉功能手术治疗的临床疗效和安全性。方法选取我院2013年1月~2016年12月收治的喉癌患者86例,作为本文的研究对象。根据研究所需,将其随机均分为两组,各43例。对照组患者实施全喉切除术,观察组患者采用喉部分切除术。比较两组患者炎性因子水平、并发症发生情况、拔管率、生存率及复发率。结果在实施手术之后的7 d,在IL-6、ESR及CRP水平方面,观察组显著低于对照组;差异有统计学意义(P<0.05)。在并发症方面,观察组的发生率为2.33%,对照组为18.60%;在拔管率方面,观察组为88.37%,对照组为69.77%,差异有统计学意义(P<0.05)。观察组3、5年生存率分别为88.37%、74.42%,均明显高于对照组的69.77%、53.49%,差异有统计学意义(P<0.05);在3、5年复发率方面,两组之间的比较差异较小,差异无统计学意义(P>0.05)。结论目前喉癌治疗的临床决策还存在很多不规范和不合理的情况,但采用喉癌保留喉功能手术,患者术后的炎症反应显著降低,而且还能提高患者拔管率及3、5年生存率,并能有效降低并发症发生率,值得在临床治疗中推广应用。Objective To explore the clinical efficacy and safety of laryngeal cancer preservation.Methods From January 2013 to December 2016,86 patients with laryngeal cancer treated in our hospital were selected as the subjects of this study.According to the needs of the institute,randomly divided into two groups,the number of patients in each group was 43.Total laryngectomy was performed in the control group,and partial laryngectomy was performed in the observation group.The levels of inflammatory cytokines,complications,tubal rate,survival rate and recurrence rate were compared between the two groups.Results In the 7d after operation,the observation group was significantly lower than the control group(P<0.05)in the level of il-6,ESR and CRP.In terms of complications,the incidence of observation group was 2.33%,and the control group was 18.60%.The observation group was 88.37%,the control group was 69.77%,and the difference between the two groups was statistically significant(P<0.05).The survival rate of the observation group was 88.37%and 74.42%respectively,which was significantly higher than 69.77%and 53.49%in the control group(P<0.05).In terms of recurrence rate in 3 and 5 years,the difference between the two groups was relatively small,which was not statistically significant(P>0.05).Conclusion Laryngeal cancer treatment of clinical decision still exist many irregularities and unreasonable situation,but the laryngeal reservation of laryngeal surgery,patients with postoperative inflammation significantly reduced,but also can increase decannulation rate and 3-5 years survival rate,and can effectively reduce the incidence of complications,worthy of popularization and application in the clinical treatment.

关 键 词：喉癌保留喉功能手术 临床疗效 安全性 

分 类 号：R739.6[医药卫生—肿瘤]