复方环磷酰胺片节拍疗法联合沙利度胺治疗高龄进展期卵巢癌7例临床分析  

Clinical analysis of elderly patients with advanced ovarian cancer treated with metronomic chemotherapy with cyclophosphamide plus thalidomide

作　　者：张帅 丁江华 ZHANG Shuai;DING Jiang-hua(171st Hospital of the PLA,Obstetrics and Gynecology Department Jiangxi Jiujiang 332000,China;171st Hospital of the PLA,Hematologic oncology department,Jiangxi Jiujiang 332000,China)

机构地区：[1]解放军第一七一医院妇产科,江西九江332000 [2]解放军第一七一医院血液肿瘤科,江西九江332000

出　　处：《临床医药文献电子杂志》2017年第81期15841-15844,共4页Electronic Journal of Clinical Medical Literature

摘　　要：目的探讨复方环磷酰胺片节拍疗法联合沙利度胺治疗高龄进展期卵巢癌患者的临床疗效与安全性。方法 7例高龄进展期卵巢癌患者,采用口服复方环磷酰胺片50 mg/d,沙利度胺片以100 mg/d为起始剂量,每晚睡前服用,视病人耐受毒副反应情况,逐渐增至150 mg/d维持治疗,如不能耐受加量则维持原剂量。每4周为一周期,每2周期评估疗效,同时观察毒副反应。结果 (1)7例患者均接受6个周期以上的治疗,5例获PR,2例获SD,ORR为71.4%(5/7),DCR为100%(7/7),中位OS为40月(18~56月)。(2)主要不良反应为Ⅰ~Ⅱ度血液学毒性、便秘与末梢神经炎,以及Ⅰ度出血性膀胱炎,经对症处理好转,未调整药物剂量。结论复方环磷酰胺片节拍疗法联合沙利度胺治疗高龄进展期卵巢癌,临床疗效较好且无明显毒副作用,具有潜在的应用前景。Objective To explore the efficacy and safety of the regimen of metronomic chemotherapy with cyclophosphamide plus thalidomide in elderly patients with advanced ovarian cancer.Methods Seven consecutive elderly patients with advanced ovarian cancer were treated with the regimen of metronomic chemotherapy with cyclophosphamide(50 mg/d)plus thalidomide(100~150mg/d).The efficacy was assessed every two cycles and every four weeks was termed as one cycle.Also,the adverse effects were recorded.Results(1)All the patients received treatment with over 6 cycles.Five cases achieved partial remission and two achieved stable disease.The overall response rate(ORR)was 71.4%and the disease control rate(DCR)was 100%.The median overall survival(OS)was 40 months(ranging from 18~56 months).(2)The main adverse effects were grade 1~2 hematological toxicities,constipation and peripheral neuritis,as well as grade1 hemorrhagic cystitis.The toxicities were alleviated after symptomatic treatment without decrease of drug dose.Conclusion The regimen of metronomic chemotherapy with cyclophosphamide plus thalidomide cause high efficacy without significant toxicities,which merits further studies.

关 键 词：复方环磷酰胺 沙利利度 节拍疗法 高龄 进展期卵巢癌 

分 类 号：R737.31[医药卫生—肿瘤]