盐酸多奈哌齐联合奥拉西坦治疗老年痴呆临床疗效研究  

A study on the clinical efficacy of doneprazidine hydrochloride combined with olasitan in the treatment of senile dementia

作　　者：张良芬[1] ZHANG Liang-fen(The geriatric department of the forty-fourth Hospital of the PLA,Guizhou Guiyang 550009,China)

机构地区：[1]解放军第44医院老年科,贵州贵阳550009

出　　处：《临床医药文献电子杂志》2017年第85期16643-16644,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的研究盐酸多奈哌齐联合奥拉西坦治疗老年痴呆的临床疗效。方法选取在我科治疗的老年痴呆患者86例,随机分成对照组与观察组,各43例,对照组采用奥拉西坦治疗,观察组采用盐酸多奈哌联合奥拉西坦治疗。结果据统计显示,观察组的MMSE评分高于对照组,且P<0.05,有明显差异。两组间的ADL评分、CDR评分对比有明显差异(P<0.05),具有统计学意义。结论采用盐酸多奈哌齐联合奥拉西坦治疗老年痴呆可以提高患者的认知力,改善患者生活能力,降低患者的痴呆程度。Objective To study the curative effect of the treatment of the treatment of senile dementia by the combination of doneprazine hydrochloride.Methods A total of 86 cases of senile dementia patients treated in our department,were randomly divided into control group and observation group,43 cases in each,the control group using oxiracetam,observation group were treated with donepezil hydrochloride combined with oxiracetam treatment.Results According to statistics,observation group MMSE score higher than the control group,and P<0.05,there is obvious difference.ADL scores,CDR score comparison between the two groups have significant difference(P<0.05),with statistical significance.Conclusion The treatment of senile dementia by using the combination of doneprazidine hydrochloride and olasetam can improve the cognition of patients,improve their living ability and reduce the degree of dementia.

关 键 词：盐酸多奈哌齐 奥拉西坦 老年痴呆 

分 类 号：R749[医药卫生—神经病学与精神病学]