非瓣膜性房颤合并脑梗死患者的血浆脑钠肽、D-二聚体水平变化及意义  

Study on serum D-dimer, NT-pro BNP in non-valvular atrial fibrillation patients with ischemic stroke

作　　者：李敏[1] 王丽娟[1] 王艳[1] LI Min;WANG Li-juan;WANG Yan(Nanjing Gulou Hospital,Suqian People's Hospital,Suqian Jiangsu 223800,China)

机构地区：[1]南京鼓楼医院集团宿迁市人民医院,江苏宿迁223800

出　　处：《临床医药文献电子杂志》2017年第73期14270-14272,共3页Electronic Journal of Clinical Medical Literature

摘　　要：目的比较房颤不伴脑梗死患者与伴脑梗死患者的血浆脑钠肽(BNP)、D-二聚体的差异,探讨BNP、D-二聚体在房颤合并脑梗死发病中的价值。方法选取我院2014年01月~2017年01月收治的房颤患者159例,其中单纯房颤患者83例(单纯房颤组);房颤伴脑梗死患者76例(伴脑梗死组);正常对照组36例。测定各组患者血浆中BNP、D-二聚体的含量,非条件Logistic回归分析评价高血压、高血糖,BNP、D-二聚体各个因素独立对房颤伴脑梗死发病的影响。结果 (1)房颤伴脑梗死组高血压、高血糖发生率更高。(2)伴脑梗死房颤患者血BNP、D-二聚体水平较不伴脑梗死组明显升高,差异有统计学意义(P<0.05)。(3)高水平的BNP、D-二聚体均是房颤伴脑梗死的危险因素(OR分别为2.038,3.191;95%CI分别为1.344~6.312及2.368~4.215)。结论单纯房颤患者及伴有脑梗死的房颤患者血BNP、D-二聚体水平明显升高,循环中存在纤溶系统异常。BNP水平、D-二聚体水平是房颤伴脑梗死发作的独立影响因素和预测指标。Objective To detect and compare the levels of NT-proBNP and D-dimer,in non-valvular atrial fibrillation patients with ischemic stroke.Methods 159 patients with atrial fibrillation treated in our hospital from 01 months to 2017 2014 were selected from 01 cases,including 83 cases of atrial fibrillation and 76 cases of atrial fibrillation patients with ischemic stroke,and 36 controls.The levels of BNP,D-dimer in patients were measured and compared among different groups.Results The levels of BNP,D-dimer in plasma of non-valvular atrial fibrillation patients with ischemic stroke were significantly increased compared with that of atrial fibrillation and controls;The levels of BNP,D-dime in plasma of atrial fibrillation were significantly increased compared with controls;The binary logistic analysis revealed that BNP and D-dime were independent causes and predictors of atrial fibrillation with ischemic stroke.Conclusions There is enhanced BNP and D-dime levels in the non-valvular atrial fibrillation patients with ischemic stroke.

关 键 词：房颤 脑梗死 脑钠肽 D-二聚体 

分 类 号：R743[医药卫生—神经病学与精神病学]