颈动脉支架置入对颈动脉狭窄患者认知功能变化与脑白质改变的相关性研究  

Study on the Correlation Between Carotid Artery Stent Implantation and Cognitive Function Change and White Matter in Patients With Carotid Artery Stenosis

作　　者：李蕾 姜国忠[2] LI Lei;JIANG Guo-zhong(Daqing Medical College,Heilongjiang Daqing 163312,China;Department of Vascular Surgery,Daqing Oilfield General Hospital,Heilongjiang Daqing 163312,China)

机构地区：[1]大庆医学高等专科学校,黑龙江大庆163312 [2]大庆油田总医院血管外科,黑龙江大庆163312

出　　处：《中西医结合心血管病电子杂志》2018年第14期70-72,共3页Cardiovascular Disease Electronic Journal of Integrated Traditional Chinese and Western Medicine

基　　金：黑龙江省卫生厅科研课题--脑血管储备联合C反应蛋白测定对颈动脉狭窄评估的研究(课题编号:2012-503)

摘　　要：目的研究给颈动脉狭窄的病人植入支架后,其认知能力改变情况同脑白质损伤程度之间的联系。方法选择126位颈动脉狭窄的中老年人患者作为受试者,所有受试者在实验开始之前都要接受MRI和血管造影检查,根据卒中量表(NIHSS)对受试者的神经功能做出评价,根据改良Rankin量表分析受试者的功能恢复程度。根据简易智力状况检查法(MMSE)、蒙特利尔认知评估量表(Mo CA)及血管性认知功能障碍测试量表中文版来评价受试者的认知程度。在实验的第3个月、6个月、12个月和18个月按照上述列表对受试者随访。结果试验后第6个月、第12个月、第18个月随访发现,受试者认知能力与Mo CA中的多项条款比实验之前有所改变,差异有统计学意义(P<0.05)。结论给颈动脉狭窄的病人植入颈动脉支架能够提高患者的认知能力。Objective To study the relationship between the change of cognitive ability and the degree of white matter injury after implantation of stent in patients with carotid artery stenosis.Methods A total of 126 middle-aged patients with carotid artery stenosis were selected as subjects.All subjects underwent MRI and angiographic examinations before the start of the experiment.According to the stroke scale(NIH Stroke Scale,NIHSS)(RSCL)according to the Rotterdam symptom checklist(RSCL)to determine the degree of impairment of the brain's white matter in patients with cognitive ability.The cognitive level of the subjects was evaluated according to the Chinese version of the mini-mentalstateexamination(MMSE),the Montreal Cognitive Assessment Scale(MoCA)and the Vascular Cognitive Impairment Test Scale.Subjects were followed up at the 3rd,6,12,and 18 months of the experiment according to the list above.Results The 6 months,12 months,18 months follow-up after the end of the trial found that the cognitive ability of the subjects and the MoCA in a number of terms than before the experiment has changed,(P<0.05).Conclusion The carotid artery stent implantation in patients with carotid artery stenosis can improve the cognitive ability of patients.

关 键 词：颈动脉支架 颈动脉狭窄 认知功能:脑白质 

分 类 号：R741[医药卫生—神经病学与精神病学]