血管生成因子AGGF1表达与结肠癌患者预后关系的研究  

Correlation of Angiogenic Factor AGGF1 Expression With Prognosis of Patients With Colon Cancer

作　　者：方瑜洁[1] 张明丽[1] FANG Yujie;ZHANG Mingli(Department of Gastroenterology,Xi’an First Hospital,Xi’an(710002))

机构地区：[1]西安市第一医院干五消化科,710002

出　　处：《胃肠病学》2018年第6期347-350,共4页Chinese Journal of Gastroenterology

基　　金：陕西省自然科学基础研究计划项目(2013JC2-14)

摘　　要：背景:血管生成在肿瘤生长和转移过程中起关键作用。AGGF1是一个新发现的血管生成因子,在多种恶性肿瘤中存在异常表达。目的:探讨AGGF1表达与结肠癌患者预后的关系。方法:收集西安市第一医院2010年1月—2012年12月80例结肠癌手术患者的癌组织和配对癌旁组织标本,以免疫组化法检测AGGF1表达。分析癌组织AGGF1表达与肿瘤临床病理特征和患者预后的关系,以Cox回归模型分析结肠癌患者的预后影响因素。结果:结肠癌组织AGGF1表达阳性率显著高于癌旁组织(67.5%对32.5%,P<0.05),并与肿瘤分化程度、淋巴结转移、血管淋巴管浸润和TNM分期显著相关(P<0.05)。Kaplan-Meier生存曲线分析显示,AGGF1阴性表达结肠癌患者的生存率显著高于AGGF1阳性表达患者(P<0.05)。单因素和多因素分析表明,AGGF1与结肠癌患者预后显著相关(OR=2.09,95%CI:1.67～4.45,P=0.011;OR=1.98,95%CI:1.72～4.59,P=0.000)。结论:结肠癌组织中血管生成因子AGGF1表达显著升高,并与肿瘤转移和患者预后不良相关,是一个潜在的预后指标,值得进一步深入研究。Background:Angiogenesis plays a critical role in tumor growth and metastasis.AGGF1,a new member of angiogenic factors,has been shown to be aberrantly expressed in a variety of malignant tumors.Aims:To investigate the correlation of AGGF1 expression with prognosis of patients with colon cancer.Methods:Eighty colon cancer patients undergoing surgical operation from Jan.2010 to Dec.2012 at Xi’an First Hospital were recruited.Immunohistochemistry was performed to evaluate the expression of AGGF1 in cancerous and paired paracancerous tissues.The correlations of AGGF1 expression in cancerous tissue with clinicopathological characteristics and prognosis were analyzed.Cox regression model was used to identify the prognostic factors of colon cancer.Results:AGGF1 expression was significantly higher in colon cancer tissue than in paracancerous tissue(67.5%vs.32.5%,P<0.05),and was correlated with tumor differentiation,lymph node metastasis,vascular/lymphatic infiltration and TNM stage(P<0.05).Kaplan-Meier survival analysis showed that high AGGF1 expression was correlated with decrease of survival rate in colon cancer patients(P<0.05).Univariate and multivariate analyses identified AGGF1 as a prognostic factor of patients with colon cancer(OR=2.09,95%CI:1.67-4.45,P=0.011;OR=1.98,95%CI:1.72-4.59,P=0.000).Conclusions:Angiogenic factor AGGF1 is up-regulated and correlated with tumor metastasis and unfavorable prognosis in patients with colon cancer.It might be a potential prognostic indicator and deserves further study.

关 键 词：血管生成蛋白质类 AGGF1 结肠肿瘤 预后 

分 类 号：R735.35[医药卫生—肿瘤]