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作 者:何明森 伏添 王成立 马丽[1] 李刚[1] HE Mingsen;FU Tian;WANG Chengli;MA Li;LI Gang(ICU,3201 Hospital,Hanzhong,Shaanxi,723000,China)
机构地区:[1]西安交通大学医学院附属三二〇一医院重症医学科,陕西汉中723000
出 处:《肿瘤药学》2018年第3期440-443,共4页Anti-Tumor Pharmacy
摘 要:目的探讨低分子肝素钠和普通肝素钠在恶性肿瘤患者下肢深静脉血栓中的预防效果及安全性。方法选择2015年3月~2017年5月医院收治的恶性肿瘤患者90例,随机数字法分为对照组(n=45)和观察组(n=45)。对照组采用普通肝素钠预防治疗,观察组采用低分子肝素钠预防治疗,采用CA7000全自动血液分析仪测定两组患者治疗前后的凝血因子指标,采用普生血流测试仪测定两组患者治疗前后的血液流变学水平,比较两组患者的临床预防效果及安全性。结果治疗后7 d,两组患者不良反应发生率比较,差异无统计学意义(P>0.05);观察组下肢深静脉血栓发生率显著低于对照组(P<0.05);观察组血小板计数、PT、APTT水平均显著低于对照组(P<0.05);观察组FIB水平显著高于对照组(P<0.05);两组治疗前血液流变学水平比较,差异无统计学意义(P>0.05);治疗后观察组血液流变学水平显著低于对照组(P<0.05)。结论低分子肝素钠有助于降低恶性肿瘤患者下肢深静脉血栓发生率,改善凝血因子及血液流变学水平,安全性较高,值得临床推广应用。Objective To investigate the effect of low-molecular-weight heparin and unfractionated heparin in preventing deep venous thrombosis of lower extremity of patients with malignant tumor.Methods 90 patients with malignant tumor treated in hospital between May 2015 and May 2017 were randomly divided into control group(n=45)and observation group(n=45).The control group was treated with unfractionated heparin sodium,while,the observation group was treated with low molecular weight heparin sodium.The CA7000 automatic blood analyzer was used to measure the coagulation factors before and after treatment.And the level of hemorheology was measured by Pusheng blood flow tester before and after treatment.The preventive effect and safety of the two groups were compared.The clinical preventive effect and safety of the two groups were compared.Results There was no significant difference in the incidence of adverse reactions between the two groups after treatment for 7 days(P>0.05).The incidence of deep vein thrombosis in the lower limbi of the observation group was lower than that of the control group(P<0.05).The levels of platelet counts,PT and APTT at 7 days after treatment in the observation group were all lower than those in the control group(P<0.05).The level of FIB in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the hemorheology level between the two groups before treatment(P<0.05).The level of hemorheology in the observation group was lower than that in the control group after treatment(P<0.05).Conclusion Low-molecularweight heparin sodium can help reduce the incidence of deep venous thrombosis of lower extremities for patients with malignant tumor and improve blood coagulation factor and hemorheology levels.It is safe and worthy to be popularized and applied.
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