神经甾体在抑郁发作治疗中的作用  

Roles of neurosteroids in the treatment of depressive episodes

作　　者：崔旅纯 洪武[1] 方贻儒[1,2,3] CUI Lü-chun;HONG Wu;FANG Yi-ru(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;State Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China;Shanghai Key Laboratory of Psychotic Disorders,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030 [2]中国科学院上海生命科学院神经科学研究所,中国科学院脑智卓越中心,上海200031 [3]上海市重性精神病重点实验室,上海200030

出　　处：《上海交通大学学报（医学版）》2018年第6期685-689,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：科技部重大慢性非传染性疾病防控研究(2016YFC1307100);国家自然科学基金面上项目(81771465)。

摘　　要：神经甾体是中枢神经系统中调节神经功能的关键性分子,在各种生理与病理过程中调控着人类的情绪及行为。神经甾体与抑郁发作的病理机制密切相关,为抑郁障碍、双相障碍等精神障碍提供了新的治疗选择。该文就神经甾体在抑郁发作治疗中作用的研究进展进行综述。Neurosteroids are the key molecules in the central nervous system that modulate neural functions.They can influence human mood and behavior in various physiological and pathophysiological situations.Neurosteroids have been implicated in the pathogenesis of depressive episodes,providing innovative therapies for psychiatric disorders such as depressive disorder and bipolar disorder.This paper reviewed the research progress on the role of neurosteroids in the treatment of depressive episodes.

关 键 词：抑郁发作 神经甾体 抑郁障碍 双相障碍 

分 类 号：R749.4[医药卫生—神经病学与精神病学]