双相情感障碍Ⅰ型患者脑灰质体积变化的偏侧性  

Lateralization of grey matter volume alterations in patients with bipolar disorder Ⅰ type

作　　者：曹龙龙 王静娟 聂彬彬[3,4] 杨晴 薛志敏 刘哲宁[6] Cao Longlong;Wang Jingjuan;Nie Binbin;Yang Qing;Xue Zhimin;Liu Zhening(Tianjin Anding Hospital,Tianjin 300222,China;Xuanwu Hospital Capital Medical University,Beijing 100053,China;Beijing Engineering Research Center of Radiographic Techniques and Equipment,Institute of High Energy Physics, Chinese Academy of Sciences,Beijing 100049,China;School of Nuclear Science and Technology,University of Chinese Academy of Sciences,Beijing 100049,China;Massachusetts General Hospital,Boston 02114,USA;Institute of Mental Health,the Second Xiangya Hospital of Central South University,Changsha 410011,China)

机构地区：[1]天津安定医院,天津300222 [2]首都医科大学宣武医院,北京100053 [3]中国科学院高能物理研究所,北京市射线成像技术与装备工程技术研究中心,北京100049 [4]中国科学院大学,核科学与技术学院,北京100049 [5]马萨诸塞州总医院,波士顿02114 [6]中南大学湘雅二医院精神卫生研究所,湖南长沙410011

出　　处：《四川精神卫生》2018年第3期209-213,共5页Sichuan Mental Health

基　　金：国家自然科学基金(81171287)

摘　　要：目的探索双相情感障碍I型患者脑灰质体积的变化,进一步研究双相情感障碍I型的病理生理学机制。方法于2012年1月-2014年7月,随机入组22例符合《精神障碍诊断与统计手册(第4版)》(DSM-IV)诊断标准的双相情感障碍I型患者(患者组)和25名健康对照组,两组年龄、性别及受教育年限匹配良好(P均>0.05)。收集两组头部结构相磁共振影像资料,使用SPM8对结构相影像资料进行分割、标准化、平滑,采用两独立样本t检验,分析两组灰质体积有统计学差异的脑区。结果与对照组相比,患者组灰质体积降低的脑区包括右侧颞上回(P<0.01)、右侧中央前回(P<0.01)及右侧楔叶(P<0.01);患者组灰质体积增大的脑区包括左侧小脑上部(P<0.01)、左侧颞中回(P<0.01)及左侧颞下回(P=0.001)。结论与健康对照组相比,双相情感障碍I型患者灰质体积降低的脑区主要集中于右侧,体积增大的脑区主要集中于左侧。Objective To explore alteration of brain grey matter volume in patients with bipolar disorder(BD)I type,to further explore the underlying pathophysiology mechanisms of BD I subtype.Methods From January 2012 to July 2014,25 healthy controls(control group)and 22 BD I patients(patient group)which well-matched in age,gender and education(all P>0.05)were enrolled at random.Specially,BD I patients were included according to the diagnosis criterion of Diagnostic and Statistical Manual of Mental Disorder,fourth edition(DSM-IV)strictly.All subjects underwent cranial structural magnetic resonance imaging(MRI)scan and the image data were collected.SPM8 software was used to estimate and write image data.Two independent samples t-test was used to calculate clusters of significant difference in grey matter volume between two groups.Results Compared with the control group,patient group exhibited decreased grey matter volume scattered in brain areas including right superior temporal gyrus(P<0.01),right precentral gyrus(P<0.01),right cuneus(P<0.01);patient group exhibited increased grey matter volume in the left cerebellum superior(P<0.01),left middle temporal gyrus(P<0.01),left inferior temporal gyrus(P=0.001).Conclusion Compared with healthy controls,BD I patients exhibited decreased grey matter volume dominantly dispersed in the right cerebrum,while increased in the left,mostly.

关 键 词：双相情感障碍 磁共振成像 基于体素的形态学分析 灰质体积 

分 类 号：R749.4[医药卫生—神经病学与精神病学]