生酮饮食治疗儿童难治性癫痫的临床研究  

Clinical Study of Ketogenic Diet in Children with Refractory Epilepsy

作　　者：许海泉[1] XU Hai-quan(Department of Neurology,Tianjin Children's Hospital,Tianjin 300074,China)

机构地区：[1]天津市儿童医院神经内科,天津300074

出　　处：《医学信息》2018年第6期83-86,共4页Journal of Medical Information

摘　　要：目的对生酮饮食治疗小儿难治性癫癎的疗效及安全性研究。方法选取自2012年8月~2017年3月天津市儿童医院神经内科74例难治性癫痫患儿,使用生酮饮食方案进行治疗。随访治疗3个月时临床发作频率及不良反应。结果 65例(88.00%)坚持治疗3个月,其中30例(46.20%)癫痫发作减少>50.00%,11例(16.90%)发作完全缓解。治疗期间的不良反应包括低血糖、腹泻、拒食、高血脂、肾结石等,可自行或经对症治疗后缓解。结论生酮饮食方案治疗小儿难治性癫痫有效且较安全。Objective To study the efficacy and safety of ketogenic diet in the treatment of children with intractable epilepsy.Methods 74 children with refractory epilepsy at the Department of Neurology,Tianjin Children's Hospital from August 2012 to March 2017 were selected and treated with a ketogenic diet.Clinical seizure frequency and adverse reactions at follow-up treatment for 3 months.Results 65 cases(88.00%)adhered to the treatment for 3 months,among which 30 cases(46.20%)had a>50.00%reduction in seizures and 11 cases(16.90%)had complete remission.Adverse reactions during treatment include hypoglycemia,diarrhea,antifeedant,hyperlipidemia,kidney stones,etc.,which can be relieved after self-treatment or symptomatic treatment.Conclusion The ketogenic diet regimen is effective and safe for the treatment of children with refractory epilepsy.

关 键 词：生酮饮食 儿童 难治性癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学]