儿茶酚胺氧位甲基转移酶基因Val158Met多态性与帕金森病抑郁的相关性  

Relationship between Val158Met Polymorphism in Catechol-O-methyltransferase Gene and Depression in Parkinson's Disease

作　　者：马惠姿[1] 马凌燕[1] 冯涛[1,2,3] MA Hui-zi;MA Ling-yan;FENG Tao(Center for Neurodegenerative Disease,Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;China National Clinical Research Center for Neurological Disease,Beijing 100050,China;Parkinson's Disease Center,Beijing Institute for Brain Disorder,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京天坛医院神经病学中心神经变性病科,北京市100050 [2]国家神经系统疾病临床医学研究中心,北京市100050 [3]北京脑重大疾病研究院帕金森病研究所,北京市100050

出　　处：《中国康复理论与实践》2018年第7期753-756,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：脑重大疾病数据的采集规范及挖掘分析研究(一期)(No.Z151100003915117);北京市自然科学基金项目(No.7164254);国家自然科学基金面上项目(No.81571226;No.81771367);首都特色临床应用研究(No.Z171100001017041);北京市科委基金项目(No.Z151100003915150);"十三五"国家重点研发计划(No.2016YFC1306501)~~

摘　　要：目的探讨儿茶酚胺氧位甲基转移酶(COMT)基因Val158Met多态性与中国帕金森病抑郁的相关性。方法 2016年6月至2017年12月,散发帕金森病患者268例,根据汉密尔顿抑郁量表评定结果分为抑郁组(n=116)和非抑郁组(n=152)。同时招募252例既往健康,无神经系统疾病,性别、年龄与患者相匹配的健康体检者作为对照组。两组留取外周血,提取基因组DNA。采用限制性片段长度多态性-聚合酶链反应(PCR-RELP)和限制性酶切,分析COMT基因Val158Met多态性。结果抑郁组、非抑郁组、对照组在COMT基因Val158Met位点基因型(χ~2=0.78,P>0.05)、等位基因(χ~2=0.25,P>0.05)分布均无显著性差异。结论 COMT基因Val158Met多态性并非中国帕金森病抑郁人群的遗传易感因素。Objective To explore the relationship between the polymorphism of catechol-O-methyltransferase(COMT)gene Val158Met site and depression in Parkinson's disease.Methods From June,2016 to December,2017,a cohort of 268 Chinese patients with Parkinson's disease and 252 ageand gender-matched healthy control subjects were recruited.The patients were divided into depression group(n=116)and non-depression group(n=152)according to Hamilton Depression Scale score.Their blood samples were collected and the polymorphism of Val158Met was carried out using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results No difference was identified in Val158Met polymorphism of genotype(χ2=0.78,P>0.05)and allele(χ2=0.25,P>0.05)among the depression group,the non-depression group and the control group.Conclusion The polymorphism of Val158Met in COMT gene does not contribute to the risk of depression in Parkinson's disease in China.

关 键 词：帕金森病 抑郁 儿茶酚胺氧位甲基转移酶 Val158Met 多态性 

分 类 号：R742.5[医药卫生—神经病学与精神病学]