失眠与腺苷信号及免疫功能的研究进展  

Research Progress of Insomnia and Adenosine Signaling and Immune Function

作　　者：任重阳 葛义俊[2] 张梅[3] REN Chong-yang;GE Yi-jun;ZHANG Mei(Anhui University of Science and Technology,Huainan 232000,Anhui,China;Chaohu Hospital of Anhui Medical University,Chaohu 238000,Anhui,China;The First People's Hospital of Huainan City/The First Affiliated Hospital of Anhui University of Science and Technology,Huainan 232000,Anhui,China)

机构地区：[1]安徽理工大学,安徽淮南232000 [2]安徽医科大学附属巢湖医院,安徽巢湖238000 [3]淮南市第一人民医院/安徽理工大学第一附属医院,安徽淮南232000

出　　处：《医学信息》2018年第10期4-6,10,共4页Journal of Medical Information

基　　金：2017年淮南市科技计划项目:帕罗西汀对应激性慢性失眠小鼠的治疗作用及其机制研究(编号:2017A0593);2016年安徽高校自然科学研究项目:慢性失眠患者的下丘脑-垂体-肾上腺轴的表观遗传修饰(编号:KJ2016A322)

摘　　要：失眠是尽管有合适睡眠环境和机会仍对睡眠时间和(或)睡眠质量不满足,并影响日间功能的一种主观体验。随着社会进步和生活节奏的加快,失眠的发病率逐渐升高并影响了人们的生活、工作。腺苷信号及免疫炎症机制参与失眠的发生,成为近年来研究的热点。本文将对失眠与腺苷信号及免疫功能的研究进展进行综述,以期探索失眠机制研究的方向和临床治疗中新的作用靶点。Insomnia is a subjective experience that influences sleep time and/or sleep quality,despite having a suitable sleep environment and opportunity,and affects daytime function.With the progress of society and the acceleration of the pace of life,the incidence of insomnia is gradually increasing and affecting people's lives and work.Adenosine signal and immune inflammation mechanism participate in the occurrence of insomnia,which has become a hot topic in recent years.This article will review the research progress of insomnia and adenosine signal and immune function,in order to explore the direction of insomnia research and new targets in clinical treatment.

关 键 词：失眠 睡眠障碍 腺苷 免疫稳态 

分 类 号：R741[医药卫生—神经病学与精神病学]