livin蛋白在肺癌胸腔积液中的表达及其评估晚期肺癌预后的价值  

Livin protein expression level in pleural effusion of lung cancer patients and its prognostic value for advanced lung cancer patients

作　　者：谢军平[1] 彭赖水 徐慧 牛琳霞 杨梅 袁世洋 陶晓南[2] XIE Junping;PENG Laishui;XU Hui;NIU Linxia;YANG Mei;YUAN Shi-yang;TAO Xiaonan(Department of Respiratory and Critical Care Medicine,The Second Affiliated Hospital of Nan.chang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院呼吸与危重症医学科,南昌330006 [2]华中科技大学同济医学院附属协和医院呼吸科,武汉430022

出　　处：《实用医学杂志》2018年第13期2099-2103,共5页The Journal of Practical Medicine

基　　金：江西省科技厅对外科技合作项目(编号:20144BDH80013);江西省自然科学基金项目(编号:20161BAB205265);江西省卫生与计划生育委员会科研课题(编号:20155304)

摘　　要：目的检测晚期肺癌患者胸腔积液中livin蛋白水平,并评估其对肺癌伴胸腔积液患者诊断及预后的价值。方法收集肺癌合并胸腔积液患者72例,良性肺部病变伴胸腔积液患者65例,用酶联免疫吸附实验测定胸腔积液中livin蛋白水平。结果肺癌组中胸腔积液livin蛋白水平为(2.58±0.07)ng/mL,显著高于对照组(0.89±0.04)ng/mL,livin蛋白水平对诊断肺癌的最佳切分值为2.43 ng/mL,其敏感性为67.00%,特异性为73.10%。肺癌患者胸腔积液livin蛋白≤2.43 ng/mL者总生存期明显比胸腔积液livin蛋白>2.43 ng/mL者长。Cox比例风险回归分析显示,肺癌患者胸腔积液中高livin蛋白水平是肺癌患者不良预后的独立指标。结论胸腔积液livin蛋白水平可作为肺癌伴胸腔积液诊断及预后评判的独立指标。Objective To investigate the expression of livin protein in pleural effusion in patients with advanced lung cancer and evaluate its value in the diagnosis and prognosis of the patients.Methods Seventy?two patients with lung cancer complicated with pleural effusion were collected as lung cancer group and another 65 with benign lung disease complicated with pleural effusion as control group.The level of livin protein in pleural effusion was measured.Results The livin protein level in pleural effusion in lung cancer group was significantly higher than that in control group.ROC curve analysis showed the optimal cut?off value of livin protein level for the diagno?sis of lung cancer was 2.43 ng/mL,with a sensitivity of 67.00%and a specificity of 73.10%.Survival curve analysis showed that the overall survival rate of lung cancer patients with livin protein level≤2.43 ng/mL was significantly higher than that of livin protein level>2.43 ng/mL.Cox proportional hazards regression analysis indicated that high livin protein level in pleural effusion of lung cancer patients was an independent predictor of adverse outcomes in lung cancer patients.Conclusion Livin protein levels in pleural effusion is of significance for the diagnosis of lung cancer and is an independent prognostic indicator in lung cancer patients.

关 键 词：LIVIN蛋白 诊断 预后 肺癌 胸腔积液 

分 类 号：R734.2[医药卫生—肿瘤]