碳酸酐酶Ⅸ在肿瘤中的研究进展  

Research Progress of Carbonic Anhydrase Ⅸ in Cancer

作　　者：江立基 李先明[1] JIANG Li-ji;LI Xian-ming(Department of Tumor Radiotherapy,Shenzhen People's Hospital,Second Clinical College of Jinan University,Shenzhen 518020,Guangdong,China)

机构地区：[1]暨南大学第二临床学院深圳市人民医院肿瘤放疗科,广东深圳518020

出　　处：《医学信息》2018年第3期7-9,共3页Journal of Medical Information

基　　金：深圳市科技研发资金资助(项目编号:JCYJ20150403102020229)

摘　　要：碳酸酐酶Ⅸ属于跨膜蛋白酶,分布于细胞膜和细胞核,CAⅨ基因是乏氧诱导因子-1(HIF-1)的下游靶基因,乏氧条件能诱导其表达并且与肿瘤的发生发展、治疗敏感性及患者预后相关。近年来CAⅨ已成为一个肿瘤潜在的靶向治疗热点,本文就CAⅨ在肿瘤中的研究进展作一综述。Carbonic anhydraseⅨis a transmembrane protease located in the cell membrane and nucleus.CAⅨgene is a downstream target of hypoxia-inducible factor-1(HIF-1),under hypoxic conditions can induce its expression and with the development of tumors,the treatment of sensitivity and patient prognosis.In recent years,CAⅨhas become a potential target of cancer therapy.This article reviews the research progress of CAⅨin cancer.

关 键 词：碳酸酐酶Ⅸ 肿瘤 乏氧诱导因子-1 

分 类 号：R730[医药卫生—肿瘤]