APE1在非小细胞肺癌脑转移中表达特点及其与预后的关系  

Features of APE1 expression in non-small cell lung cancer with brain metastases and its relationship with prognosis

作　　者：夏蕾[1] 肖何[1] 李梦侠[1] 杨镇洲 王东[1] XIA Lei;XIAO He;LI Mengxia;YANG Zhenzhou;WANG Dong(Cancer Center,the Third Affiliated Hospital of Army Medi.cal Uiversity,Chongqing 400042,China;Department of Oncology,the Second Affiliated Hospital of Chongqing Medical Universi.ty,Chongqing 400010,China;;)

机构地区：[1]陆军军医大学大坪医院野战外科研究所肿瘤中心,重庆400042 [2]重庆医科大学附属第二医院肿瘤科,重庆400010

出　　处：《现代医药卫生》2018年第14期2105-2110,2115,共7页Journal of Modern Medicine & Health

基　　金：陆军军医大学大坪医院野战外科研究所青年创新基金(2014YQN02)

摘　　要：目的研究脱嘌吟脱嘧啶核酸内切酶1(APE1)在非小细胞肺癌肺原发灶及脑转移灶中的表达水平及亚细胞定位特点,探讨其与治疗敏感性及预后的相关性。方法收集2010年1月至2015年1月陆军军医大学大坪医院11例肺原发灶及脑转移灶均经过手术切除且病理确诊为非小细胞肺癌脑转移患者的临床资料,应用免疫组织化学方法检测肺原发灶及脑转移灶APE1蛋白表达水平及亚细胞定位,分析其与患者客观有效率(ORR)、疾病控制率(DCR)、无病生存期(DFS)及总生存期(OS)的相关性。结果 11例肺原发灶中7例APE1高表达,脑转移灶中9例APE1高表达;肺原发病灶及脑转移病灶APE1的表达水平一致者为6例(54.5%),且均为高表达;APE1表达水平与肺原发灶或脑转移灶疗效及预后呈负相关(P<0.05)。结论 APE1在有脑转移的非小细胞肺癌中总体呈高表达,且脑转移灶的表达有增高和胞质异位表达趋势;APE1高表达和胞质异位表达可能作为治疗反应差及预后不良的标志。Objective Objective To investigate the expression and subcellular localization features of apurinic/apyrimidinic endonuclease1(APE1)in primary and brain metastatic tumors of nonsmall cell lung cancer(NSCLC)patients,and examine their impacts on treatment sensitivity and prognosis.Methods A total of 11 patients pathologically confirmed NSCLC with brain metastases participated in the present study.APE1 expression and subcellular localization for primary tumor and brain metastases tumors were detected by immunohistochemistry.Association between APE1 expression pattern and objective responserate(ORR),diseasecontrolrate(DCR),diseasefreesurvival(DFS)andoverallsurvival(OS)wasexplored.Results High expression of APE1 was detected in 7 patients'primary tumor tissues and 9 patients'brain metastatic tumor tissues.High expression levels of APE1 in PPT or brain metastases were negatively associated with therapeutic effects and prognosis(P<0.05).Conclusion The current findings suggest that APE1 expression is generally high in BMT of patients with NSCLC,particularly in the cytoplasm.Elevated total and cytoplasmic APE1 may indicate a poor treatment response and poor prognosis in patients with NSCLC with brain metastases.

关 键 词：APE1 非小细胞肺癌 脑转移 敏感性 预后 

分 类 号：R734.2[医药卫生—肿瘤]