A型肉毒毒素对减轻额部术后瘢痕增生的临床研究  

Effect of botulinum toxin A on reducing forehead postoperative scar

作　　者：陶谏[1] 刘宾[1] 汪阳[1] 崔鑫[1] 韩悦[1] Tao Jian;Liu Bin;Wang Yang(Department of Burn and Plastic Surgery of Xi’an Center Hospital(Xi’an 710003))

机构地区：[1]西安市中心医院烧伤整形外科,西安710003

出　　处：《陕西医学杂志》2018年第8期1011-1013,共3页Shaanxi Medical Journal

基　　金：陕西省科技厅社会发展攻关项目(2015SF-160)

摘　　要：目的:观察早期肉毒素A局部注射对降低额部瘢痕增生的效果。方法:40例需要行额部肿物切除手术的患者随机分成两组,在术后72h内注射或不注射肉毒素A(BTXA)。对患者进行为期1年的随访,使用患者瘢痕评估量表(PSAS)、温哥华瘢痕量表(VSS)以及视觉模拟量表(VAS)对术后切口瘢痕进行评估打分。结果:在1年的随访中,36例患者被复查,4例患者失访。两组之间在PSAS方面没有统计学差异(P>0.05)。而肉毒素A治疗组的VSS及VAS评分与对照组相比结果均具有统计学差异(P<0.05),表明术后肉毒素A注射有降低瘢痕增生的作用。结论:由于可以抑制肌肉收缩而降低伤口局部张力,因此注射肉毒素A可以降低瘢痕增生的程度从而改善额部伤口缝合后的美容效果。Objective:To observe the effect of early local injection of botulinum toxin(BTA)A on reducing hypertrophic scar in the frontal area.Methods:Forty patients who required a nephrectomy surgery were enrolled in this study.They were divided into two groups,with or without BTA injection within 72 hours after surgery.The patients were followed for a period of one year.Postoperative scars were scored using the Patient Scar Rating Scale(PSAS),Vancouver scar scale(VSS)and the Visual Analogue Scale(VAS).Results:During the 1-year follow-up,36 patients were reviewed and 4 patients were lost.There was no statistically significant difference in the PAS between the two groups.However,the score of VAS and VSS between treatment group and the control group has a statistically significant difference,demonstrating that postoperative BTA injection has a role in reducing scar hyperplasia.Conclusion:By inhibiting muscle contraction and reducing the local tension of the wound,injection of BTA can reduce the scar hyperplasia and improve the cosmetic outcome of the forehead wound.

关 键 词：瘢痕 肉毒杆菌毒素类 A型 额 

分 类 号：R782.05[医药卫生—口腔医学]